Non-invasive Ultrasound Stimulated Retinal Prosthesis
无创超声刺激视网膜假体
基本信息
- 批准号:10376213
- 负责人:
- 金额:$ 49.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-04-01 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAcoustic StimulationAddressAge related macular degenerationAnimalsBiologicalBiomedical EngineeringBiophysical ProcessBlindnessBrainCellsChemicalsComplexDevicesElectric StimulationElectrophysiology (science)ElementsEngineeringEvaluationEyeEye diseasesGoalsHippocampus (Brain)In VitroInstitutesInvestigationLeadMedicineMotor CortexNeural RetinaNeuronsOperative Surgical ProceduresOphthalmologyOryctolagus cuniculusPersonsPhasePhotoreceptorsPhysiologic pulseProsthesisProtocols documentationRattusResearchResolutionRetinaRetinal DegenerationRetinal PhotoreceptorsRetinitis PigmentosaSalamanderStimulusSurgeonSystemTechnologyTestingTissuesTransducersTranslatingUltrasonic TransducerUltrasonicsUltrasonographyValidationVisually Impaired Personscollegecostdesignimaging modalityimplantable deviceimplantationin vivoin vivo evaluationmultidisciplinaryneural networknovel strategiesrelating to nervous systemresponseretinal neuronretinal prosthesisretinal stimulationsight restorationspatiotemporalsuperior colliculus Corpora quadrigeminatoolultrasound
项目摘要
Abstract
Age-related macular degeneration and retinitis pigmentosa lead to loss of retinal photoreceptor cells, causing
blindness in thousands of people each year. Retinal prosthetic devices treat these incurable conditions by
electrically or chemically stimulating surviving retinal neurons with implanted devices in the eye. However,
existing devices are very expensive, invasive, and require complex implantation surgeries. Here we propose to
explore a new approach in retinal prosthetics that is entirely noninvasive. Previous studies have demonstrated
the feasibility of ultrasound to elicit neural activity in the rat hippocampus and motor cortex, and salamander
retina cell. We recently demonstrated that a focused single element ultrasound transducer can elicit spiking
activity in mammalian retinal neurons. In order to develop potential ultrasound prosthetic devices, we have to
overcome several technical challenges:
1) Engineer an ultrasound device that is safe and effective (i.e., optimized) for retinal stimulation.
2) Develop three-dimensional mapping of neural activity in the retinal neural network under acoustic
stimulation. Such an imaging method is essential for studying the biological mechanism of ultrasound
stimulation and functional evaluation of ultrasound stimulation protocols.
The goal of this study is to develop ultrasound stimulation by using phased array that can potentially replace
invasive prosthetic electrical stimulation for retina. The first, we will develop specialized ultrasonic single-
element transducer/phased arrays for retinal stimulation; we will design an optimal ultrasound stimulation
paradigm to produce controllable and consistent retinal responses with high spatiotemporal resolution. The
purpose of this study is two-fold: 1) to investigate biophysical mechanisms of ultrasound stimulation on retinal
neurons, and 2) to conduct functional testing of the ultrasound devices developed. Finally, in vitro and in vivo
rabbit studies using integrated ultrasound stimulation will be developed.
摘要
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Flexible ultrasound-induced retinal stimulating piezo-arrays for biomimetic visual prostheses.
- DOI:10.1038/s41467-022-31599-4
- 发表时间:2022-07-04
- 期刊:
- 影响因子:16.6
- 作者:Jiang, Laiming;Lu, Gengxi;Zeng, Yushun;Sun, Yizhe;Kang, Haochen;Burford, James;Gong, Chen;Humayun, Mark S.;Chen, Yong;Zhou, Qifa
- 通讯作者:Zhou, Qifa
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Qifa Zhou其他文献
Qifa Zhou的其他文献
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{{ truncateString('Qifa Zhou', 18)}}的其他基金
Biomechanical mapping of the optic nerve head and peripapillary sclera using high frequency ultrasonic elastography
使用高频超声弹性成像对视神经乳头和视乳头周围巩膜进行生物力学测绘
- 批准号:
10712180 - 财政年份:2021
- 资助金额:
$ 49.01万 - 项目类别:
Biomechanical mapping of the optic nerve head and peripapillary sclera using high frequency ultrasonic elastography
使用高频超声弹性成像对视神经乳头和视乳头周围巩膜进行生物力学测绘
- 批准号:
10531275 - 财政年份:2021
- 资助金额:
$ 49.01万 - 项目类别:
Biomechanical mapping of the optic nerve head and peripapillary sclera using high frequency ultrasonic elastography
使用高频超声弹性成像对视神经乳头和视乳头周围巩膜进行生物力学测绘
- 批准号:
10356053 - 财政年份:2021
- 资助金额:
$ 49.01万 - 项目类别:
Non-invasive Ultrasound Stimulated Retinal Prosthesis
无创超声刺激视网膜假体
- 批准号:
9902498 - 财政年份:2019
- 资助金额:
$ 49.01万 - 项目类别:
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