Non-invasive Ultrasound Stimulated Retinal Prosthesis

无创超声刺激视网膜假体

• 批准号: 10376213
• 负责人: Qifa Zhou
• 金额: $ 49.01万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10376213
• 关键词: 3-Dimensional; Acoustic Stimulation; Address; Age related macular degeneration; Animals; Biological; Biomedical Engineering; Biophysical Process; Blindness; Brain; Cells; Chemicals; Complex; Devices; Electric Stimulation; Electrophysiology (science); Elements; Engineering; Evaluation; Eye; Eye diseases; Goals; Hippocampus (Brain); In Vitro; Institutes; Investigation; Lead; Medicine; Motor Cortex; Neural Retina; Neurons; Operative Surgical Procedures; Ophthalmology; Oryctolagus cuniculus; Persons; Phase; Photoreceptors; Physiologic pulse; Prosthesis; Protocols documentation; Rattus; Research; Resolution; Retina; Retinal Degeneration; Retinal Photoreceptors; Retinitis Pigmentosa; Salamander; Stimulus; Surgeon; System; Technology; Testing; Tissues; Transducers; Translating; Ultrasonic Transducer; Ultrasonics; Ultrasonography; Validation; Visually Impaired Persons; college; cost; design; imaging modality; implantable device; implantation; in vivo; in vivo evaluation; multidisciplinary; neural network; novel strategies; relating to nervous system; response; retinal neuron; retinal prosthesis; retinal stimulation; sight restoration; spatiotemporal; superior colliculus Corpora quadrigemina; tool; ultrasound

Abstract Age-related macular degeneration and retinitis pigmentosa lead to loss of retinal photoreceptor cells, causing blindness in thousands of people each year. Retinal prosthetic devices treat these incurable conditions by electrically or chemically stimulating surviving retinal neurons with implanted devices in the eye. However, existing devices are very expensive, invasive, and require complex implantation surgeries. Here we propose to explore a new approach in retinal prosthetics that is entirely noninvasive. Previous studies have demonstrated the feasibility of ultrasound to elicit neural activity in the rat hippocampus and motor cortex, and salamander retina cell. We recently demonstrated that a focused single element ultrasound transducer can elicit spiking activity in mammalian retinal neurons. In order to develop potential ultrasound prosthetic devices, we have to overcome several technical challenges: 1) Engineer an ultrasound device that is safe and effective (i.e., optimized) for retinal stimulation. 2) Develop three-dimensional mapping of neural activity in the retinal neural network under acoustic stimulation. Such an imaging method is essential for studying the biological mechanism of ultrasound stimulation and functional evaluation of ultrasound stimulation protocols. The goal of this study is to develop ultrasound stimulation by using phased array that can potentially replace invasive prosthetic electrical stimulation for retina. The first, we will develop specialized ultrasonic single- element transducer/phased arrays for retinal stimulation; we will design an optimal ultrasound stimulation paradigm to produce controllable and consistent retinal responses with high spatiotemporal resolution. The purpose of this study is two-fold: 1) to investigate biophysical mechanisms of ultrasound stimulation on retinal neurons, and 2) to conduct functional testing of the ultrasound devices developed. Finally, in vitro and in vivo rabbit studies using integrated ultrasound stimulation will be developed.

摘要

项目成果

Flexible ultrasound-induced retinal stimulating piezo-arrays for biomimetic visual prostheses.

• DOI: 10.1038/s41467-022-31599-4
• 发表时间: 2022-07-04
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Jiang, Laiming;Lu, Gengxi;Zeng, Yushun;Sun, Yizhe;Kang, Haochen;Burford, James;Gong, Chen;Humayun, Mark S.;Chen, Yong;Zhou, Qifa
• 通讯作者: Zhou, Qifa