Development of separation processes using ionic liquids

使用离子液体的分离工艺的开发

• 批准号: 17560670
• 负责人: MATSUMOTO Michiaki
• 金额: $ 2.43万
• 依托单位: Doshisha University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17560670/
• 关键词: Ionic liquid; Separation process; Liquid membrane; Membrane separation; Extraction; Optical resolution; Whole-cell biocatalysis; Organic acid; バイオプロセス; 固定化酵素; 抗生物質

1) In this study, we examine whether room-temperature ionic liquids (RTILs) as a membrane solution can be utilized for hydrocarbon separation from petroleum, and organic acid and penicillin G from the fermented broth by using supported liquid membrane. We used the hexafluorophosphates of 1-n-butyl-, 1-n-hexyl-and 1-n-octyl-3-methyl imidazolium and quaternary ammonium salts as an ionic liquid. The supported liquid membrane was prepared by impregnating the porous polyvinylidene fluoride film with the ionic liquid. Organic sulfur and nitrogen compounds, peniciliin G and lactic acid were successfully transported through the membrane based on the ionic liquids.(2) Enantiopure chemicals are important in pharmaceutical and agricultural, because each enantiomer shows different activity for human body. Specially, chiral diols are one of the most excellent compounds as intermediate materials, therefore enantiopure preparation method is required. Ionic liquid is a novel medium for enzymatic reactions and has characteristics such as nonvolatile, inflame ability, thermal stability and high polarity. It has shown high stability and enantioselectivity in enzymatic reaction. In this research, it was performed kinetic resolution of rac-epoxides by epoxide hydrolase, which has enantioselectivity, for preparing enantiopure diol in biphasic system of buffer/ionic liquid. Epoxide hydrolase from Rhodotorula glutinis, which had reported for high enantioselectivity for 1,2-epoxyhexane as substrate, was used for this research. Epoxide hydrolase from Rhodotorula glutinis ATCC201718 shows high catalytic activity without being extracted from whole-cell, and excellent enantioselectivity for R-enantiomer was confirmed.

1）在本研究中，我们研究了室温离子液体（RTIL）作为膜溶液是否可以用于从石油中分离烃类，以及通过使用支撑液膜从发酵液中分离有机酸和青霉素G。我们使用1-正丁基-、1-正己基-和1-正辛基-3-甲基咪唑鎓和季铵盐的六氟磷酸盐作为离子液体。通过用离子液体浸渍多孔聚偏二氟乙烯膜来制备负载液膜。有机硫和氮化合物、青霉素G和乳酸成功地通过基于离子液体的膜进行运输。(2)对映体纯化学品在制药和农业中具有重要意义，因为每种对映体对人体表现出不同的活性。特别是，手性二醇是最优秀的中间体化合物之一，因此需要对映体纯的制备方法。离子液体是一种新型的酶促反应介质，具有不挥发、难燃、热稳定性和高极性等特点。它在酶促反应中表现出高度的稳定性和对映选择性。本研究利用具有对映选择性的环氧化物水解酶对外消旋环氧化物进行动力学拆分，在缓冲液/离子液体双相体系中制备对映纯二醇。本研究使用来自粘红酵母的环氧化物水解酶，据报道该酶对 1,2-环氧己烷作为底物具有高对映选择性。来自粘红酵母 ATCC201718 的环氧化物水解酶无需从全细胞中提取即可显示出高催化活性，并且证实了对 R-对映体具有优异的对映选择性。

项目成果

Separation of aromatic hydrocarbons with supported liquid membrane based on ionic liquids

基于离子液体的支撑液膜分离芳烃

• 发表时间: 2005
• 期刊: Proceedings of the 7^<th> International Conference on Separation Science and Technology Between Korea and Japan-
• 作者: Hideto Yoshida;Umi Norimoto;Kunihiro Fukui;Hideto Yoshida;秋山聡;H.Yoshida;H.Yoshida;松本 道明;松本 道明;松本 道明;松本 道明;Michiaki Matsumoto et al.;Michiaki Matsumoto et al.;Michiaki Matsumoto et al.;Michiaki Matsumoto et al.;松本 道明;上羽健太郎
• 通讯作者: 上羽健太郎

Separation of benzene/cyclohexane mixture through supported liquid membranes with an ionic liquid

使用离子液体通过支撑液膜分离苯/环己烷混合物

• 发表时间: 2006
• 期刊: Solvent Extraction Research and Development, Japan 13
• 作者: Hideto Yoshida;Umi Norimoto;Kunihiro Fukui;Hideto Yoshida;秋山聡;H.Yoshida;H.Yoshida;松本 道明;松本 道明
• 通讯作者: 松本 道明

Comparison of solvent extraction and supported liquid membrane permeation using an ionic liquid for concentrating penicillin G

• DOI: 10.1016/j.memsci.2006.11.046
• 发表时间: 2007-02
• 期刊: Journal of Membrane Science
• 影响因子: 9.5
• 作者: M. Matsumoto;Tokihito Ohtani;Kazuo Kondo

Extraction of penicillin G with ionic liquids

离子液体提取青霉素G

• 发表时间: 2006
• 期刊: Proceedings of the 11^<th> Asian Pacific Confederation of Chemical Engineering 2006
• 作者: Hideto Yoshida;Umi Norimoto;Kunihiro Fukui;Hideto Yoshida;秋山聡;H.Yoshida;H.Yoshida;松本 道明;松本 道明;松本 道明;松本 道明
• 通讯作者: 松本 道明

Selective separation of aromatic hydrocarbons through supported liquid membranes based on ionic liquids

• DOI: 10.1016/j.memsci.2004.08.013
• 发表时间: 2005-01-01
• 期刊: JOURNAL OF MEMBRANE SCIENCE
• 影响因子: 9.5
• 作者: Matsumoto, M;Inomoto, Y;Kondo, K
• 通讯作者: Kondo, K