The spinocerebellar evoked response as an option of monitoring for inferior cerebellar peduncle dysfunction

脊髓小脑诱发反应作为监测小脑下脚功能障碍的一种选择

• 批准号: 17591523
• 负责人: KODAMA Namio
• 金额: $ 1.47万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591523/
• 关键词: cerebellum; evoked potential; inferior cerebellar peduncle; intraoperative monitoring; rat; spinocerebellar tract; intraoperative monitoring; 小脳; 誘発電位; 下小脳脚; 術中モニタリング; 脊髄小脳路

The aim of this study was to develop a new method for the intraoperativemonitoring of inferior cerebellar peduncle (Inf.C.Ped) function. As the dorsal spinocerebellar tract (SCT) is located in the Inf.C.Ped, we studied the possibility of using the evoked potential elicited by stimulation of the dorsal SCT and recorded from the cerebellar surface to assess the Inf.C.Ped function.The experimental study was performed in rats. Unilateral muscular contractions of quadriceps femoris muscle were elicited by electrical stimulation. The evoked potentials were recorded from the surface of the ipsilateral cerebellum and the contralateral primary sensory cortex. The highly reproducible potentials obtained from the ipsilateral cerebellar hemisphere were named spinocerebellar evoked potentials (SCEP). The SCEP exhibited one negative peak with a latency of 11.7 ± 0.3 msec (N11). Short latency somatosensory evoked potential (SSEP) was recorded from the contralateral primary sensory cortex with a latency of 19.1 ± 0.6 msec. Coagulation of the ipsilateral Inf.C.Ped caused disappearance or marked reduction of the SCEP N11 but it did not change the SSEP. On the other hand, sectioning of the ipsilateral dorsal column resulted in the disappearance of the SSEP but it did not affect the SCEP N11.Reproducible SCEP was recorded from the rat cerebellar hemisphere by electrical stimulation of the quadriceps femoris muscle. We posit that the SCEP differs from the SSEP which ascends via the dorsal column and that it is conducted by the dorsal SCT located in the Inf.C.Ped. Our results suggest that it may be possible to monitor the Inf.C.Ped in patients during cerebellar surgery.

本研究的目的是开发一种术中监测小脑下脚 (Inf.C.Ped) 功能的新方法。由于脊髓小脑背束（SCT）位于Inf.C.Ped中，我们研究了利用刺激背侧SCT引起并从小脑表面记录的诱发电位来评估Inf.C.Ped功能的可能性。该实验研究在大鼠中进行。通过电刺激引起股四头肌的单侧肌肉收缩。从同侧小脑和对侧初级感觉皮层的表面记录诱发电位。从同侧小脑半球获得的高度可重复的电位被命名为脊髓小脑诱发电位（SCEP）。 SCEP 表现出一个负峰，潜伏期为 11.7 ± 0.3 毫秒 (N11)。从对侧初级感觉皮层记录短潜伏期体感诱发电位 (SSEP)，潜伏期为 19.1 ± 0.6 毫秒。同侧 Inf.C.Ped 凝固导致 SCEP N11 消失或显着减少，但不改变 SSEP。另一方面，同侧背柱的切片导致 SSEP 消失，但不影响 SCEP N11。通过电刺激股四头肌，从大鼠小脑半球记录可重复的 SCEP。我们假设 SCEP 与通过背柱上升的 SSEP 不同，它是由位于 Inf.C.Ped 的背侧 SCT 进行的。我们的结果表明，在小脑手术期间监测患者的 Inf.C.Ped 是可能的。