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Development of non-invasive tool for evaluating neural activity of brain thalamus, anterior cingulated cortex, and prefrontal cortex in pain patients using ^1H-MRS.

开发非侵入性工具，使用 ^1H-MRS 评估疼痛患者的大脑丘脑、前扣带皮层和前额叶皮层的神经活动。

基本信息

批准号：
17591625
负责人：
FUKUI Sei
金额：
$ 2.24万
依托单位：
Shiga University of Medical Science
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591625/
关键词：
MR spectroscopy anterior cingulated gyrus prefrontal cortex thalamus 視床

项目摘要

We investigated the absolute concentration of N-acetylaspartate (NAA) in the thalamus, anterior cingulated cortex (ACC), and prefrontal cortex (PFC), in chronic pain patients by proton magnetic resonance spectroscopy (^1H-MRS).^1H-MRS was performed with a 1.5T MR system on a voxel in the thalamus, ACC, and PFC bilaterally, in 48 chronic pain patients and 23 normal control subjects. We measured the absolute concentration of NAA using a LC-Model.The 26 patients whose NAA concentration in the ACC or PFC decreased significantly, compared to the mean NAA concentration of the normal control subjects, needed psychological approach. ^1H-MRS suggest that NAA concentration in the ACC or PFC seems to be associated with the necessity of psychological approach.^1H-MRS may serve as a useful non-invasive tool for evaluating neural activity of thalamus, anterior cingulated cortex, and prefrontal cortex in chronic pain patients.

我们用质子磁共振波谱（^1H-MRS）研究了慢性疼痛患者丘脑、前扣带皮层（ACC）和前额叶皮层（PFC）中N-乙酰天冬氨酸（NAA）的绝对浓度。应用1.5T磁共振系统对48例慢性疼痛患者和23例正常对照者进行双侧丘脑、前交叉韧带（ACC）和前额叶皮质（PFC）的1H-MRS检查。我们用LC模型测定了NAA的绝对浓度，其中26例患者ACC或PFC的NAA浓度较正常对照组明显降低，需要心理干预。^~ 1H-MRS提示ACC或PFC中NAA浓度与心理治疗的必要性有关。1H-MRS可作为评价慢性疼痛患者丘脑、前扣带皮层和前额叶皮层神经活动的一种有用的无创性工具。