Establishment of non-invasive tool for evaluating brain neural activity in chronic pain patients using magnetic resonance spectroscopy.

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In patients with chronic pain and CRPS, in the anterior cingulate gyrus, compared to healthy volunteers, the average left NAA concentration was significantly decreased.In chronic neuropathic patients and CRPS patients, compared with less anxious patients, NAA concentrations in the anterior cingulate gyrus was significantly decreased in the patients with strong anxiety accompanying chronic pain.^1H-MRS was evaluated for regional brain function, and could be considered a useful way to evaluate changes in pain processing mechanisms in the brain.As a pilot study,in healthy subjects, using a 3T MRI system, glutamate concentration and GABA concentration were measured in anterior cingulate gyrus.In the anterior cingulate gyrus in patients with chronic pain, excitatory neurons in the brain, the concentration of the neurotransmitter glutamate, the inhibitory neurons, the concentration of the neurotransmitter GABA, ready to be measured now. Using ^1H-MRS, evaluation of neural activity of excitatory neurons and the inhibitory neurons in the brain become possible.