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Analysis of histopathology and genetic polymorphism in the patients of peritoneal dialysis and kidney transplantation

腹膜透析及肾移植患者组织病理学及基因多态性分析

基本信息

批准号：
17591680
负责人：
TSUCHIDA Masahiro
金额：
$ 2.24万
依托单位：
Yamaguchi University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

项目摘要

1. We studied the factors for the survival rate and technical survival in the peritoneal dialysis patients. We also studied the effects of genetic polymorphisms of interleukin 1 receptor agonist (IL-1Ra) on the prognosis of peritoneal dialysis patients. Materials and methods: One hundred twenty-nine patients who started peritoneal dialysis in our related institutions were retrospectively analyzed. Genetic polymorphism of IL-1Ra was analyzed by PCR method. Clinical data was also recorded. The relationships of genetic polymorphism of IL-1Ra or clinical data and the survival rate and technical survival in the peritoneal dialysis patients, were analyzed by multivariate analysis.Results : The frequency of the genetic polymorphisms of IL-1RN * 1/ IL-1RN * 1 and IL-1RN * 1/ IL-1RN * 2 were 84.5% and 15.5%, respectively. The median of survival was 37 months that was predicted by the patients age, cardiovascular complications and serum albumin. The median of peritoneal dialysis duration was 32 … More months. Thirty-seven patients discontinued peritoneal dialysis. The technical survival for 2 and 5 years were 92.0% and 72.7%, respectively. The independent factors for prognosis were serum albumin, the frequency of peritonitis and the existence of genetic polymorphism of IL-1RN * 2.2. We studied the effects of genetic polymorphism of interleukin 1 β (IL-1(3) on chronic allograft nephropathy (CAN) afterrenal transplantation.Materials and methods : Twenty-seven Patients who were performed protocol biopsy at the times of 1 month and 1 year after renal transplantation were analyzed. In these patients, the relationships of the polymorphism of IL-1 β (SNPs of IL-1 /3) and the results of protocol biopsy or clinical data were analyzed.Results : The SNPs of IL-1 β-511(location : Exon 5) were C/C (8 cases; 29.6 %), C/T (15 cases; 55.6 %) and T/T (4 cases; 14.8 %). CAN was observed in 5 cases in the group of C/C (62.5 %), 9 cases in the group of C/T (60.0 %) and 2 cases in the group of T/T (50.0 %). No significant differences were observed in these three groups. Less

1. 我们研究了影响腹膜透析患者生存率和技术生存率的因素。我们还研究了白细胞介素1受体激动剂（IL-1Ra）基因多态性对腹膜透析患者预后的影响。材料与方法：回顾性分析我院收治的129例腹膜透析患者的资料。采用PCR方法分析IL-1Ra基因多态性。同时记录临床资料。采用多因素分析方法分析IL-1Ra基因多态性与腹膜透析患者生存率及技术生存率的关系。结果：IL-1RN * 1/ IL-1RN * 1和IL-1RN * 1/ IL-1RN * 2基因多态性频次分别为84.5%和15.5%。中位生存期为37个月，由患者年龄、心血管并发症和血清白蛋白预测。腹膜透析持续时间中位数为32个月。37例患者停止腹膜透析。2年和5年技术生存率分别为92.0%和72.7%。影响预后的独立因素为血清白蛋白、腹膜炎发生频率及IL-1RN * 2.2基因多态性的存在。我们研究了白细胞介素1 β (IL-1(3))基因多态性对肾移植后慢性同种异体肾病（CAN）的影响。材料与方法：分析27例在肾移植术后1个月和1年进行方案活检的患者。在这些患者中，分析IL-1 β多态性（IL-1 /3 snp）与方案活检结果或临床数据的关系。结果：IL-1 β-511（位置：外显子5）snp为C/C（8例，29.6%）、C/T（15例，55.6%）和T/T（4例，14.8%）。C/C组5例（62.5%），C/T组9例（60.0%），T/T组2例（50.0%）。三组间无明显差异。少