Assessment of fetal autonomic nervous system activity by fetal magnetocardiography: Comparison of normal pregnancy and intrauterine growth restriction

胎儿心磁图评估胎儿自主神经系统活动：正常妊娠与宫内生长受限的比较

• 批准号: 17591753
• 负责人: FUKUSHIMA Akimune
• 金额: $ 2.24万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591753/
• 关键词: Intrauterine growth restriction; fetal magnetocardiography; heart rate variability; autonomic nervous system; 発生・分化; 磁性; 胎児

Aim : To clarify the developmental activity of the autonomic nervous system (ANS) of the normal fetus and to compare developmental activity between normal pregnancy and the case of intrauterine growth restriction (IUGR) using fetal magnetocardiography (FMCG).Methods : Subjects consisted of normal pregnancy (n = 35) and IUGR (n = 12) cases at 28-39 and 32-37 weeks gestation, respectively. FMCG was recorded using 64-channel magnetocardiography (MCG) in a magnetically shielded room. The QRS interval was derived from signal-averaged MCG; the R由 interval variability induced by an R-wave trigger was eventually adopted to calculate the coefficient of variance (CVRR) and low frequency/high frequency (LF/HF) ratio.Results : The value of CVRR in the normal pregnancy group displayed a slight increasing trend with gestational age (y = 1.77 + 0.10x ; r = 0.32) ; however, no such trend was observed in the IUGR group. In contrast, the LF/HF ratio in the normal pregnancy group clearly increased over the gestational period (one-way ANOVA: P = 0.003). The LF/HF ratio in the IUGR group also displayed an increasing trend over the gestational period (y = 2.47 + 0.05x ; r = 0.05).Conclusions : Analyses based on the time and frequency domains of heart rate variability using FMCG enable the evaluation of fetal ANS activity. Sympathetic nervous activity increased with gestational age in the normal pregnancy group ; however, the development of fetal ANS activity in IUGR cases might differ from that observed in the normal pregnancy group.

Aim : To clarify the developmental activity of the autonomic nervous system (ANS) of the normal fetus and to compare developmental activity between normal pregnancy and the case of intrauterine growth restriction (IUGR) using fetal magnetocardiography (FMCG).Methods : Subjects consisted of normal pregnancy (n = 35) and IUGR (n = 12) cases at 28-39 and 32-37 weeks gestation, respectively. FMCG was recorded using 64-channel magnetocardiography (MCG) in a magnetically shielded room. The QRS interval was derived from signal-averaged MCG; the R was induced by interval variability by an R-wave trigger was eventually adopted to calculate the coefficient of variation (CVRR) and low frequency/high frequency (LF/HF) ratio.Results : The value of CVRR in the normal pregnancy group displayed a slight increasing trend with gestational age (y = 1.77 + 0.10x ; r = 0.32) ; however, no such trend was observed in the IUGR group. In contrast, the LF/HF ratio in the normal pregnancy group clearly increased over the gestational period (one-way ANOVA: P = 0.003). The LF/HF ratio in the IUGR group also displayed an increasing trend over the gestational period (y = 2.47 + 0.05x ; r = 0.05).Conclusions : Analyses based on the time and frequency domains of heart rate variability using FMCG enable the evaluation of fetal ANS activity. Sympathetic nervous activity increased with gestational age in the normal pregnancy group ; however, the development of fetal ANS activity in IUGR cases might differ from that observed in the normal pregnancy group.

项目成果

Assessment of fetal autonomic nervous system activity and heart rate variability by magnetocardiography : Comparison of normal pregnancy and intrauterine growth retardation

通过心磁图评估胎儿自主神经系统活动和心率变异性：正常妊娠与宫内生长迟缓的比较

• 期刊: The Journal of Japan Biomagnetium and Bioelectromagnetics Society Vo1.18 No.1
• 作者: Akimune Fukushima;Rie Oyama;Jun Murotsuki;Toshihiko Izutsu;Toru Sugiyama;Masato Yoshizawa;Kenji Nakai
• 通讯作者: Kenji Nakai

64チャンネル心磁計の開発と臨床応用

64通道心磁图仪的研制及临床应用

• 发表时间: 2006
• 期刊: 臨床病理 58・8
• 作者: 中居 賢司;福島 明宗
• 通讯作者: 福島 明宗

心磁図を用いた胎児の心拍変動と自律神経活動の評価-正常と子宮内胎児発育遅延の比較-

使用心磁图评估胎儿心率变异性和自主神经活动 - 正常和宫内生长迟缓的比较 -

• 发表时间: 2005
• 期刊: 日本生体磁気学会誌特別号 18・1
• 作者: 中居 賢司;福島 明宗;福島 明宗;福島明宗
• 通讯作者: 福島明宗

Assessment of fetal autonomic nervous system activity and heart rate variability by fetal magnetocardiography : Comparison of normal pregnancy and intrauterine growth restriction.

通过胎儿心磁图评估胎儿自主神经系统活动和心率变异性：正常妊娠和宫内生长受限的比较。

• 期刊: The Journal of prenatal Diagnosis (In Press)
• 作者: Akimune Fukushima;Rie Oyama;Jun Murotsuki et al.
• 通讯作者: Jun Murotsuki et al.

胎児心磁図により出生前診断を行った胎児心室頻拍の一例

使用胎儿心磁图产前诊断胎儿室性心动过速的一个例子

• 发表时间: 2006
• 期刊: 日本生体磁気学会誌特別号 19・1
• 作者: 平井 康夫;et. al.;福島明宗
• 通讯作者: 福島明宗