Fetal Magnetocardiography Using Non-cryogenic Magnetic Field Sensors

使用非低温磁场传感器进行胎儿心磁图检查

• 批准号: 8313846
• 负责人: Vishal K Shah
• 金额: $ 19.74万
• 依托单位: QUSPIN
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-15 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8313846
• 关键词: Adopted; Adult; Agreement; Arrhythmia; Capital; Cardiac; Clinical; Congenital Heart Defects; Development; Diagnosis; Diagnostic; Disease; Electrocardiogram; Electronics; Electrophysiology (science); Engineering; Ensure; Environment; Evaluation; Fetal Heart Rate; Fetus; Floor; Frequencies; Goals; Gold; Heart Rate; Human; Institutes; Lasers; Letters; Life; Light; Magnetism; Measurement; Measures; Metals; Methods; Noise; Optics; Patients; Performance; Phase; Physics; Play; Price; Private Sector; Production; Pump; Relaxation; Reliance; Reporting; Research; Resolution; Second Pregnancy Trimester; Signal Transduction; Skin; Speed; Surface; System; Techniques; Technology; Temperature; Testing; Ultrasonography; Universities; Validation; Wisconsin; Work; base; biomagnetism; cost; cost effective; cost effectiveness; cryogenics; design; digital; experience; fetal; fetus at risk; flexibility; heart rhythm; high risk; innovation; magnetic field; non-invasive system; patient safety; sensor; superconducting quantum interference device; tool

DESCRIPTION (provided by applicant): The goal of this project is to develop a low cost, non-invasive system for diagnosis of serious heart rate and rhythm abnormalities in fetus. Postnatally, electrocardiography (ECG) is the gold standard for rhythm assessment. In the fetus, however, the quality of the ECG is too poor for clinical use due to low conductivity of the fetal skin and vernix, which restricts the electrical currents generated by fetal cardiac activity from reaching the maternal surface. In recent years, fetal magnetocardiography (fMCG) has emerged as a promising new tool that overcomes the weaknesses of fetal ECG by detecting magnetic fields instead of electric potentials generated by fetal cardiac activity. Despite its high efficac, fMCG has not been widely adopted due to its reliance on superconductor technology, which is prohibitively expensive and cumbersome. The system that we propose to develop will use latest room-temperate optical magnetometers to drastically reduce the cost of fMCG. Currently, the cost of a fully functional fMCG system is approximately one million dollars. The proposed technology can reduce the price of an fMCG system to $100,000. PUBLIC HEALTH RELEVANCE: The goal of the research is to develop a new magnetic sensor technology for fetal magnetocardiography, a highly promising method of assessing serious fetal heart rate and rhythm disorders. The new sensor technology, which is based on principles of atomic physics, is far more practical and cost-effective than the current technology, which is based on superconductor physics.

描述（由申请人提供）：本项目的目标是开发一种低成本、无创的系统，用于诊断胎儿严重心率和心律异常。出生后，心电图（ECG）是心律评估的金标准。然而，在胎儿中，ECG的质量对于临床使用而言太差，这是由于胎儿皮肤和胎脂的低导电性，这限制了由胎儿心脏活动产生的电流到达母体表面。近年来，胎儿心磁图（fMCG）已成为一个有前途的新工具，克服了胎儿心电图的弱点，通过检测磁场，而不是由胎儿心脏活动产生的电位。尽管其高效，但由于其对超导技术的依赖，快速消费品尚未被广泛采用，超导技术过于昂贵和笨重。我们建议开发的系统将使用最新的室温光学磁力计，以大幅降低快速消费品的成本。目前，一个功能齐全的快速消费品系统的成本约为100万美元。该技术可以将快速消费品系统的价格降低到10万美元。 公共卫生关系：该研究的目标是开发一种用于胎儿心磁图的新磁传感器技术，这是一种非常有前途的评估严重胎儿心率和心律紊乱的方法。基于原子物理学原理的新传感器技术比基于超导体物理学的现有技术更实用和更具成本效益。