Localization of ASICs in the sensory nervous system in the head and neck under chronic hypoxia.

1.二氧化碳对颈动脉体结构的影响：系统性低氧大鼠颈动脉体增大，高二氧化碳低氧组颈动脉体平均直径小于低二氧化碳组和等二氧化碳低氧组。缺氧时颈动脉体的形态学改变可能与动脉CO2张力有关。（Hierarchy Hitopathol.20：987.997，2005，Adv.Exp.Med.Biol.580：55-61，2006）。缺氧习服和去习服时颈动脉体的形态学变化：缺氧2、4和8周的颈动脉体平均直径分别是常氧对照组的1.2、1.4和1.6倍。慢性缺氧结束后1周，颈动脉体缩小。缺氧结束后8周，颈动脉体的大小与常氧对照组相似。（Histol.Histol.20：987-997，2005，Adv.Exp.Med.Biol.580：49-54，2006）。慢性低氧改变了味蕾中钙结合蛋白D-28 k的免疫反应性，舌味蕾中钙结合蛋白D-28 k的免疫反应性在慢性低氧下降低。在喉味蕾中，低氧大鼠的Calbindin D-28 k免疫反应纤维比常氧大鼠多。（Histol.Histol.21：1271-1276，2006年。

1. Effect of carbon dioxide on the structure of the carotid body.The carotid bodies of the systemic hypoxic rats were found to be enlarged, and the mean diameter of the hypercapnic hypoxic carotid bodies were smaller than the hypocapnic and isocapnic hypoxic carotid bodies. The morphological changes in the hypoxic carotid bodies may depend on the arterial CO2 tension. (Histol Hitopathol.20:987.997, 2005, Adv.Exp.Med.Biol.580:55-61, 2006).2. Morphological changes in the carotid body in acclimatization and deacclimatization to hypoxia.The mean diameter of the carptid bodies exposed to hypoxia for 2, 4, and 8 weeks was 1.2, 1.4, and 1.6 times longer than in normoxic controls. The carotid bodies 1 week after the termination of chronic hypoxia were diminished in size. The carotid bodies 8 weeks after the termination of hypoxia were similar to the normoxic controls in size. (Histol.Histopathol.20:987-997, 2005, Adv.Exp.Med.Biol.580:49-54, 2006).3. Chronic hypoxia alters calbindin D-28k immunoreactivity in the taste buds.Calbindin D-28k immunoreactivity in the lingual taste buds was decreased under chronic hypoxia. In the laryngeal taste buds calbindin D-28k immumoreactive fibers in hypoxic rats were more than in normoxic rats. (Histol.Histopathol.21:1271-1276, 2006.