Morphological studies on the chemoreceptors of spontaneously hypertensive rats(SHR).

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The carotid bodies, which are located at the carotid bifurcation and are the primary chemoreceptive organs for sensing changes in arterial blood gases, became significantly enlarged in spontaneously hypertensive rats(SHR). In spite of enlargement, there was no obvious vascular enlargement in SHR. SHR showed a significant increase in extracellular matrix in the carotid body. These results indicate that the mechanism of carotid body enlargement in SHR is different from that in hypoxic animals. In addition, the present studies suggest facilitated noradrenaline biosynthesis in chemoreceptor cells of carotid bodies in SHR.