Development of Bioabsorbable Micro-Device for Alveolar Bone Gain

本研究开发了一种可通过热塑性成型的纳米复合材料可生物吸收的微型器件。生物可吸收微型装置如TCP/PLGC具有通过热混合的复合β-磷酸三钙和聚-（L-丙交酯-co-乙交酯-co-ε-己内酯）。并通过体内、体外实验研究了该装置的力学性能和牙槽骨生长机制，结果表明，该装置具有良好的机械强度和生物可吸收性。TCP/PLGC铆钉与骨相吻合，对微型装置有较好的固定作用，将网状微型装置植入大鼠颅骨，可形成良好的成骨效果。在边缘骨缺损和开窗术中，将微型装置植入犬下颌骨，植入后12周证实有骨形成。将复合TCP的微型装置移植到20 mm长的胫骨骨缺损处，12周后证实了可行走的骨形成，表明研制的可吸收微型装置有助于骨的获得和再生治疗。

In this research, bioabsorbable micro device of the nano composite which can be molded to free form by thermoplasticity was developed. Bioabsorbable micro device as TCP/PLGC have composite β-Tricalcium Phosphate and Poly- (L-lactide-co-glycolide-co-ε-caprolactone) by heat-mixing. And the mechanical property of a device and mechanism of alveolar bone gain were studied by in vitro and in vivo.Consequently, micro device had mechanical strength and bioabsorbable required for bone regeneration. The TCP/PLGC rivet fitted the bone and certainly fixed the micro device.When micro device of mesh form was implanted to Rats calvaria, it was form effective in bone formation. In marginal bone defects and fenestration, when micro device was implanted to canine mandibular, bone formation was confirmed 12 weeks after the implantation. Moreover, when the micro device which combined TCP was transplanted to bone defects of 20mm in length of tibia, the bone formation which can be walked 12 weeks after the implantation was confirmed.It was suggested that developed bioabsorbable micro device contributes to bone gain and regeneration treatment.