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Development of Bioabsorbable Micro-Device for Alveolar Bone Gain

生物可吸收微装置的开发用于牙槽骨增加

基本信息

批准号：
17592018
负责人：
KOYAMA Yoshihisa
金额：
$ 0.96万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17592018/
关键词：
Nano-Composite Device Alveolar Bone Gain 生体吸収性材料膜状材料リベット

项目摘要

In this research, bioabsorbable micro device of the nano composite which can be molded to free form by thermoplasticity was developed. Bioabsorbable micro device as TCP/PLGC have composite β-Tricalcium Phosphate and Poly- (L-lactide-co-glycolide-co-ε-caprolactone) by heat-mixing. And the mechanical property of a device and mechanism of alveolar bone gain were studied by in vitro and in vivo.Consequently, micro device had mechanical strength and bioabsorbable required for bone regeneration. The TCP/PLGC rivet fitted the bone and certainly fixed the micro device.When micro device of mesh form was implanted to Rats calvaria, it was form effective in bone formation. In marginal bone defects and fenestration, when micro device was implanted to canine mandibular, bone formation was confirmed 12 weeks after the implantation. Moreover, when the micro device which combined TCP was transplanted to bone defects of 20mm in length of tibia, the bone formation which can be walked 12 weeks after the implantation was confirmed.It was suggested that developed bioabsorbable micro device contributes to bone gain and regeneration treatment.

在本研究中，开发了一种生物可吸收的纳米复合材料微器件，该器件可通过热塑性成型形成自由形态。TCP/PLGC是由β-磷酸三钙和聚- （l -乳酸-共乙醇-co-ε-己内酯）复合材料热混合而成的生物可吸收微器件。并对该装置的力学性能和牙槽骨生长机制进行了体外和体内实验研究。因此，微装置具有骨再生所需的机械强度和生物可吸收性。TCP/PLGC铆钉贴合骨，当然固定了微型装置。网状微装置植入大鼠颅骨后，成骨效果明显。在边缘骨缺损和开窗情况下，将微装置植入犬下颌骨，植入12周后证实成骨。此外，将结合TCP的微型装置移植到长度为20mm的胫骨骨缺损上，证实植入12周后骨形成可行走。研究结果表明，开发的生物可吸收微型装置有助于骨增重和再生治疗。