Future for Clinician Scientists in Precision Metabolic Medicine

代谢性疾病与终末器官损害的复杂模式有关，如肝脏、心血管、神经血管，但也与恶性疾病有关。今天，与代谢性疾病相关的系统-通信-网络的变化只在当前的护理系统中没有得到充分的反映，这些系统面向学科边界，而不是对每个患者的整体看法。这一应用的假设是，在现有学科之间的交界处的跨器官诊断、风险预测、预防和治疗概念(“精准代谢医学”)将在代谢性疾病的基础和转化研究以及未来的患者护理领域具有最高的创新潜力。“精确代谢医学中临床医生科学家的未来”旨在通过临床医生科学家计划中的多个学科相互联系来克服学科界限，以塑造将代谢性疾病作为整体、跨学科的医学和科学挑战的新一代临床医生科学家。该申请建立在该领域的卓越表现以及海因里希·海涅大学杜塞尔多夫大学医学院和杜塞尔多夫大学医院的创新合作结构的基础上。未来四年--CSPMM将把现有供资方案和协作提案(CRCs等)联系起来。拥有新的跨学科研究基础设施(例如CARDDIAB，“新陈代谢校园”)和高容量的临床护理单元。课程结构侧重于以下支柱：1.具有约束力的课程，为临床医生科学家提供受保护的研究时间，同时也使干预和外科学科方面的优秀专家培训成为可能。跨学科合作的创新概念(“新陈代谢委员会”)和将以计算机为基础的方法融入决策途径(“数据科学集成委员会”)3.通过发展特定能力加强年轻临床医生科学家的学术自主性4.加强与代谢性疾病背景特别相关的方法学方法(例如数字方法、多组学和人工智能、公共卫生、遗传学、炎症和免疫代谢、临床试验)5.通过对家庭的实际支持以及促进女性候选人和多样性，可持续地创造一个创造性和鼓舞人心的科学和临床环境该方案将向对代谢性疾病感兴趣的所有临床学科的候选人开放，并将涵盖基础科学、翻译科学和早期临床试验的研究项目。最后，未来4-CSPMM将为其参与者提供可持续的医疗、科学和结构附加值，以及海因里希·海涅大学杜塞尔多夫医学院未来的战略目标。

Metabolic diseases are associated with complex patterns of end organ damage such as hepatic, cardiovascular, neurovascular but also malignant diseases. Today, alterations of system-communication-networks associated to metabolic diseases are only inadequately reflected by current systems of care, oriented to disciplinary boundaries rather than a holistic view on each individual patient. The hypothesis of this application is that cross-organ diagnosis, risk prediction, prevention and treatment concepts ("precision metabolic medicine") at the boarders between established disciplines will have the highest innovation potential in the field of basic and translational research and future patient care for metabolic diseases. "Future for Clinician Scientists in Precision Metabolic Medicine (FUTURE-4-CSPMM)" aims at overcoming disciplinary boundaries through interconnecting multiple disciplines in a clinician scientist programme in order to shape a new generation of clinician scientists embracing metabolic diseases as a holistic, interdisciplinary medical and scientific challenge. The application builds on excellence in this field and innovative cooperation structures at the Medical Faculty of Heinrich Heine University Düsseldorf and the University Hospital Düsseldorf. FUTURE-4-CSPMM will link existing funding programmes and collaborative proposals (CRCs etc.) with new interdisciplinary research infrastructures (e.g. CARDDIAB, "Metabolic Campus") and high-volume clinical care units. The programme structure focuses on the following pillars: 1. A binding curriculum that offers clinician scientists protected research time and at the same time enables excellent specialist training also in interventional and surgical disciplines2. Innovative concepts of interdisciplinary cooperation ("Metabolic Board") and the integration of computer-based methods into decision paths ("Data Science Integration Board")3. Strengthening academic autonomy of young clinician scientists through the development of specific competences4. Strengthening methodological approaches with particular relevance to the context of metabolic diseases (e.g. digital methods, multi-omics and AI, public health, genetics, inflammation and immuno-metabolism, clinical trials)5. The sustainable creation of a creative and inspiring scientific and clinical environment through practical support for families and the promotion of female candidates and diversityThe programme will be open to candidates from all clinical disciplines interested in metabolic diseases and will cover research projects featuring basic science, translational science and early clinical trials. Finally, FUTURE-4-CSPMM will provide a sustainable medical, scientific and structural added value for its participants as well as the future strategic goals of the Medical Faculty of Heinrich Heine University Düsseldorf.