Future for Clinician Scientists in Precision Metabolic Medicine

精准代谢医学临床科学家的未来

• 批准号: 493659010
• 负责人: Professor Dr. Tom Lüdde, Ph.D.
• 金额: --
• 依托单位: Institut für Klinische Diabetologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/493659010?language=en
• 关键词: Future; Clinician; Scientists; Precision; Metabolic

Metabolic diseases are associated with complex patterns of end organ damage such as hepatic, cardiovascular, neurovascular but also malignant diseases. Today, alterations of system-communication-networks associated to metabolic diseases are only inadequately reflected by current systems of care, oriented to disciplinary boundaries rather than a holistic view on each individual patient. The hypothesis of this application is that cross-organ diagnosis, risk prediction, prevention and treatment concepts ("precision metabolic medicine") at the boarders between established disciplines will have the highest innovation potential in the field of basic and translational research and future patient care for metabolic diseases. "Future for Clinician Scientists in Precision Metabolic Medicine (FUTURE-4-CSPMM)" aims at overcoming disciplinary boundaries through interconnecting multiple disciplines in a clinician scientist programme in order to shape a new generation of clinician scientists embracing metabolic diseases as a holistic, interdisciplinary medical and scientific challenge. The application builds on excellence in this field and innovative cooperation structures at the Medical Faculty of Heinrich Heine University Düsseldorf and the University Hospital Düsseldorf. FUTURE-4-CSPMM will link existing funding programmes and collaborative proposals (CRCs etc.) with new interdisciplinary research infrastructures (e.g. CARDDIAB, "Metabolic Campus") and high-volume clinical care units. The programme structure focuses on the following pillars: 1. A binding curriculum that offers clinician scientists protected research time and at the same time enables excellent specialist training also in interventional and surgical disciplines2. Innovative concepts of interdisciplinary cooperation ("Metabolic Board") and the integration of computer-based methods into decision paths ("Data Science Integration Board")3. Strengthening academic autonomy of young clinician scientists through the development of specific competences4. Strengthening methodological approaches with particular relevance to the context of metabolic diseases (e.g. digital methods, multi-omics and AI, public health, genetics, inflammation and immuno-metabolism, clinical trials)5. The sustainable creation of a creative and inspiring scientific and clinical environment through practical support for families and the promotion of female candidates and diversityThe programme will be open to candidates from all clinical disciplines interested in metabolic diseases and will cover research projects featuring basic science, translational science and early clinical trials. Finally, FUTURE-4-CSPMM will provide a sustainable medical, scientific and structural added value for its participants as well as the future strategic goals of the Medical Faculty of Heinrich Heine University Düsseldorf.

代谢性疾病与复杂的终末器官损伤模式相关，例如肝脏、心血管、神经血管以及恶性疾病。今天，与代谢性疾病相关的系统通信网络的改变仅被当前的护理系统不充分地反映出来，这些系统面向学科边界，而不是对每个患者的整体看法。本申请的假设是，跨器官诊断、风险预测、预防和治疗概念（“精确代谢医学”）在既定学科之间的边界将在基础和转化研究以及未来代谢疾病患者护理领域具有最高的创新潜力。“精准代谢医学临床科学家的未来（FUTURE-4-CSPMM）”旨在通过在临床科学家计划中互连多个学科来克服学科界限，以塑造新一代的临床科学家，将代谢疾病作为一个整体，跨学科的医学和科学挑战。该应用程序建立在该领域的卓越成就和杜塞尔多夫海因里希海涅大学医学院和杜塞尔多夫大学医院的创新合作结构的基础上。FUTURE-4-CSPMM将把现有的供资方案和合作建议（CRC等）联系起来。新的跨学科研究基础设施（如CARDDIAB，“代谢校园”）和高容量的临床护理单位。该方案结构侧重于以下支柱：1.一个具有约束力的课程，为临床科学家提供受保护的研究时间，同时也使介入和外科学科的优秀专家培训成为可能2。跨学科合作的创新概念（“代谢委员会”）和基于计算机的方法集成到决策路径（“数据科学集成委员会”）3.通过发展特殊能力加强年轻临床科学家的学术自主权4。加强与代谢疾病背景特别相关的方法学方法（例如数字方法、多组学和人工智能、公共卫生、遗传学、炎症和免疫代谢、临床试验）5.通过对家庭的实际支持和促进女性候选人和多样性，可持续地创造一个创造性和鼓舞人心的科学和临床环境该计划将向对代谢疾病感兴趣的所有临床学科的候选人开放，并将涵盖基础科学，转化科学和早期临床试验的研究项目。最后，FUTURE-4-CSPMM将为其参与者以及杜塞尔多夫海因里希海涅大学医学院的未来战略目标提供可持续的医疗，科学和结构附加值。