Regulatory mechanism of signal transduction in the immune system.

本研究项目的目的是通过细胞因子受体、粘附分子、死亡受体、抗原受体等参与免疫应答和免疫系统发育的信号转导机制的阐明，以了解免疫系统的分子机制，阐明免疫紊乱如自身免疫性疾病的机制。我们已经开展了几项活动，1）我们对每个研究小组的研究活动进行了评估，并就技术问题向他们提供了建议。2）我们鼓励研究小组之间的合作研究。3）为使研究活动向公众开放，每年出版两次通讯，开通网站，三年半来组织了4次研讨会和8次会议。我们已经出版了7次通讯，报告我们的研究进展，并讨论与项目相关的各种问题。此外，我们还开通了网站，使我们的研究活动向公众开放。在研究项目的最后一年，我们组织了一次关于健康和疾病中免疫反应调节的国际研讨会，与国外领先的免疫学家讨论和交流过去3年取得的成果。我们邀请了23位来自国外的免疫学家，并邀请了24位日本免疫学家在研讨会期间发表演讲。

The purpose of this research project is the clarification of the signal transduction mechanisms through cytokine receptors, adhesion molecules, death receptors, antigen receptors involved in immune response and development of immune system to understand the molecular mechanisms of immune system and clarify the mechanisms of immunological disorders, such as autoimmune disease.We have performed several activities,1) We have evaluated the research activities of each research team and advised them on technical matters.2) We have stimulated collaborative research among research teams. For this purpose, we had symposium and research meeting twice a year.3) To make the research activities open to public, we have published newsletter twice a year and opened the website.We organized symposium 4 times and meeting 8 times during the last 3 and half years. We have published newsletter 7 times to report the progress of our research and discuss various problems of project-related issues. Furthermore, we opened the website to make our research activities open to public. In the last year of the research project, we organized an international symposium on regulation of immune response in health and disease to discuss and exchange the results obtained during the last 3 years with leading immunologists from abroad. We invited 23 immunologists from abroad and asked 24 Japanese immunologists to give a talk during the symposium.