Molecular Mechanisms of Heat Failure and Its Novel Therapeutic Strategies

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Heart failure is a leading cause of death in industrialized nations. Although the mainstay of treatment is pharmacotherapy including treatment with angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers and β-blockers, 1-year mortality is nearly 20% even with optimal medical therapy. Because other treatment options such as heart transplantation, ventricular assist devices and artificial hearts are not readily available to most patients, there has been a tremendous need for the development of novel treatment strategies for heart failure. As genetically altered mouse models are valid for investigating heart failure, we analyzed molecular mechanisms of heart failure using the mouse models. Furthermore, we investigated the mechanisms of cardiac regeneration to develop the novel strategies such as gene therapy, cell-based therapy and cytokine therapy.