Prediction of treatment success of dialectic behavioral therapy in borderline personality disorder

边缘性人格障碍辩证行为疗法治疗成功的预测

• 批准号: 499083365
• 负责人: Professor Dr. Simon Eickhoff
• 金额: --
• 依托单位: Klinik für Allgemeine Psychiatrie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/499083365?language=en
• 关键词: Prediction; treatment; success; dialectic; behavioral

The aim of the proposed project is to define neurobiological markers that allow to predict treatment success of dialectic behavioral therapy in Borderline personality disorder with high accuracy. To this end, we will combine functional and structural imaging data acquired using magnetic resonance imaging as well as genetic and epigenetic information in multivariate analyses.Successful prediction of treatment responses is highly desirable to allocate limited and costly treatment resources to patients which are most likely to respond and could additional improve our understanding of the underlying mechanisms of Borderline personality disorder.

拟建项目的目的是定义神经生物学标记物，使其能够高精度地预测边缘型人格障碍辨证行为治疗的治疗成功。为此，我们将结合磁共振成像获得的功能和结构成像数据以及多变量分析中的遗传和表观遗传信息。成功预测治疗反应是非常可取的，可以将有限和昂贵的治疗资源分配给最有可能做出反应的患者，并可以进一步提高我们对边缘型人格障碍潜在机制的理解。