Ultrasound waveguiding of light deep into scattering media

超声波将光波导深入散射介质

• 批准号: 499150341
• 负责人: Professor Dr. Martin Hofmann
• 金额: --
• 依托单位: Lehrstuhl für Photonik und Terahertztechnologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/499150341?language=en
• 关键词: Ultrasound; waveguiding; light; deep; into

In general, optical technologies are attractive for biomedical applications such as imaging and treatment. However, the massive scattering of light in biological tissue prevents an efficient penetration of light deeper than a few millimeters into the tissue and thus dramatically limits the potential of light for biomedical applications. Therefore, approaches to suppress or circumvent the scattering are desperately sought for. Among those concepts, the use of ultrasound for alteration of the light path via the acoustooptical effect seems particularly promising. Therefore, the aim of this project is to evaluate systematically how ultrasound waveguiding can promote light delivery deep into scattering tissue and by that enable optical and photoacoustic imaging of biomedical tissue with increased penetration depth. Based on our preliminary studies, we develop numerical models for ultrasound and light propagation in scattering media as well as for the ultrasound mediated light waveguiding. With those models, we derive optimum settings for experimental configurations. Consequently, these settings will be implemented and systematically experimentally analyzed with scattering phantoms and solutions. Finally, we combine the optimized concept with photoacoustic imaging and develop concepts for photoacoustic imaging at larger penetration depth due to ultrasound mediated light guiding. In summary, we have two main goals: 1. A comprehensive understanding of the physical effects underlying the ultrasound induced light waveguiding in scattering media 2. Demonstration of high penetration depth via ultrasound induced waveguiding in photoacoustic imaing

通常，光学技术对于成像和处理等生物医学应用具有吸引力。然而，生物组织中光的大量散射可阻止比几毫米在组织中更深的光渗透，从而极大地限制了光的潜力在生物医学应用中。因此，迫切需要抑制或规避散射的方法。在这些概念中，使用超声通过声学效应改变光路的方法似乎特别有前途。因此，该项目的目的是系统地评估超声波引导如何促进光向递送到散射组织中，并通过使生物医学组织的光学和光声成像随着渗透深度的增加而促进光学和光声成像。基于我们的初步研究，我们开发了用于超声和光传播的数值模型，以及超声介导的轻波引导。使用这些模型，我们为实验配置提供了最佳设置。因此，这些设置将通过散射幻象和解决方案进行实验，并在实验上进行实验分析。最后，我们将优化的概念与光声成像结合在一起，并开发出由于超声介导的光指导而在较大的穿透深度下进行光声成像的概念。总而言之，我们有两个主要目标：1。对超声引起的散射介质中的轻度波引导的物理效应的全面理解2。通过超声诱导的光声imaing中的超声诱导的波引导表现出高渗透深度