Ultrasound waveguiding of light deep into scattering media

超声波将光波导深入散射介质

• 批准号: 499150341
• 负责人: Professor Dr. Martin Hofmann
• 金额: --
• 依托单位: Lehrstuhl für Photonik und Terahertztechnologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/499150341?language=en
• 关键词: Ultrasound; waveguiding; light; deep; into

In general, optical technologies are attractive for biomedical applications such as imaging and treatment. However, the massive scattering of light in biological tissue prevents an efficient penetration of light deeper than a few millimeters into the tissue and thus dramatically limits the potential of light for biomedical applications. Therefore, approaches to suppress or circumvent the scattering are desperately sought for. Among those concepts, the use of ultrasound for alteration of the light path via the acoustooptical effect seems particularly promising. Therefore, the aim of this project is to evaluate systematically how ultrasound waveguiding can promote light delivery deep into scattering tissue and by that enable optical and photoacoustic imaging of biomedical tissue with increased penetration depth. Based on our preliminary studies, we develop numerical models for ultrasound and light propagation in scattering media as well as for the ultrasound mediated light waveguiding. With those models, we derive optimum settings for experimental configurations. Consequently, these settings will be implemented and systematically experimentally analyzed with scattering phantoms and solutions. Finally, we combine the optimized concept with photoacoustic imaging and develop concepts for photoacoustic imaging at larger penetration depth due to ultrasound mediated light guiding. In summary, we have two main goals: 1. A comprehensive understanding of the physical effects underlying the ultrasound induced light waveguiding in scattering media 2. Demonstration of high penetration depth via ultrasound induced waveguiding in photoacoustic imaing

一般来说，光学技术对成像和治疗等生物医学应用具有吸引力。然而，光在生物组织中的大量散射阻碍了光在组织中深度超过几毫米的有效渗透，从而极大地限制了光在生物医学应用中的潜力。因此，抑制或规避散射的方法是迫切需要的。在这些概念中，利用超声波通过声光效应来改变光路似乎特别有前途。因此，该项目的目的是系统地评估超声波导如何促进光深入散射组织，并通过增加穿透深度来实现生物医学组织的光学和光声成像。在初步研究的基础上，建立了超声光在散射介质中传播的数值模型以及超声媒质光波导的数值模型。利用这些模型，我们得出了实验配置的最佳设置。因此，这些设置将被实现并系统地实验分析散射幻影和解决方案。最后，我们将优化的概念与光声成像相结合，提出了超声介导光引导下更大穿透深度光声成像的概念。总之，我们有两个主要目标：1。对散射介质中超声诱导光波导物理效应的全面认识2。超声诱导波导在光声成像中的高穿透深度论证