Frontier studies in development and cancer

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We carried out gene trap mutagenesis using the exchangeable gene trap method and 800 gene trap clones with information of gene names and insertion sites were deposited to EGTC bank and database. The germ-line competent ES cell lines derived from the Japanese wild mouse, MSM/Ms, was established. We developed the exchangeable gene targeting method using Cre-mutant lox system. We demonstrated that the Abhd2 gene, the Skt gene, the Lgr4 gene, and the Spink3 gene are involved in migration of smooth muscle cells and differentiation of monocyte into macrophage, in tail vertebrate formation, development of epididymidis and gall bladder, and in inhibition of autophagy and cell proliferation through EGFR pathway, respectively.