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Molecular mechanisms of development of stomach cancer by Epstein-Barr virus

Molecular mechanisms of development of stomach cancer by Epstein-Barr virus
EB病毒引起胃癌的分子机制
批准号:
17013002
负责人:
TAKADA Kenzo
金额:
$34.24万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009

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中文摘要
翻译
在大多数人中,EB病毒(Epstein-Barr Virus,EBV)没有特殊的表现,但偶尔会与各种恶性肿瘤有关,包括免疫缺陷宿主的淋巴瘤和胃癌。以前,我们已经报道了EBV编码的非编码RNA(EBER)在肿瘤发生中起关键作用。在这项研究中,我们证明了EBER通过利用先天免疫系统发挥其致癌活性。
英文摘要
In most people, Epstein-Barr virus (EBV) is maintained without specific manifestations, but is occasionally associated with various malignancies including lymphoma in immunodeficient hosts and gastric carcinoma. Previously, we have reported that EBV-encoded non-coding RNA (EBER) plays critical roles in oncogenesis. In this research, we have demonstrated that EBER exerts its oncogenic activity by utilizing an innate immunity system.
期刊论文(41)
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会议论文
Epstein-Barr virus-induced oncogenesis through utilizing the innate immunity system.
EB 病毒通过利用先天免疫系统诱导肿瘤发生。
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Takada, K., Iwakiri, D., M. Samanta]
通讯作者: M. Samanta
Epstein-Barr Virus (Role of EBERs. ed. Robertson, E.S.)
Epstein-Barr 病毒(EBER 的作用。Robertson,E.S. 编)
DOI: --
发表时间: 2005
期刊:
影响因子: --
作者: [Takada, K.]
通讯作者: K.
DOI: 10.1002/mc.20133
发表时间: 2005-10
期刊: Molecular Carcinogenesis
影响因子: 4.6
作者: [H. Wong;Xianghong Wang;R. C. Chang;D. Jin;H. Feng;Qi Wang;K. Lo;D. Huang;P. Yuen;K. Takada;Y. Wong;S. Tsao]
通讯作者: H. Wong;Xianghong Wang;R. C. Chang;D. Jin;H. Feng;Qi Wang;K. Lo;D. Huang;P. Yuen;K. Takada;Y. Wong;S. Tsao
Epstein-Barr virus-encoded Bcl-2 homologue functions as a survival fact or in Burkitt lymphoma.
Epstein-Barr 病毒编码的 Bcl-2 同源物在伯基特淋巴瘤中发挥着生存事实的作用。
DOI: --
发表时间: 2010
期刊: J.Virol. 84
影响因子: --
作者: [Watanabe, A.]
通讯作者: A.
31
    The Role of Epstein-Barr virus encoded small RNAs (EBERs)
    • 批准号:
      15390147
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.86万
    • 财政年份:
      2003
    • 负责人:
      TAKADA Kenzo
    • 依托单位:
    Analysis of functions of Epstein-Barr virus-encoded small RNA EBER
    • 批准号:
      13470062
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.0万
    • 财政年份:
      2001
    • 负责人:
      TAKADA Kenzo
    • 依托单位:
    Molecular mechanisms of development of gastric carcinoma by Epstein-Barr virus
    • 批准号:
      12213001
    • 项目类别:
      Grant-in-Aid for Scientific Research on Priority Areas
    • 资助金额:
      $29.57万
    • 财政年份:
      2000
    • 负责人:
      TAKADA Kenzo
    • 依托单位:
    Development of a model animal for Epstein-Barr virus infection
    • 批准号:
      12557028
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.45万
    • 财政年份:
      2000
    • 负责人:
      TAKADA Kenzo
    • 依托单位:
    海外基金