Functional analysis of BRCA1 and BRCA2 on the mechanism of breast carcinogenesis.

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When we elucidate the molecular mechanism of breast oncogenesis, the functional analysis of BRCA1 and BRCA2 which are responsible protein for hereditary breast cancer is indispensable. BRCA2 functions in DNA damage repair at S phase, and is localized, surrounding around entrosome from the G1/S transition to the early M phase of the cell cycle. When the cytokinesis begins, BRCA2 is localized in the mid-body. Therefore, we tried to clarify the role of BRCA2 protein, and find out how BRCA2 contributes to incidence of breast cancer.