Role of the RNA-primase GANP in cancer development

RNA引物酶 GANP 在癌症发展中的作用

• 批准号: 17013069
• 负责人: SAKAGUCHI Nobuo
• 金额: $ 23.81万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17013069/
• 关键词: 発がん; 老化; RNA輸送; 乳癌; プライマーゼ; 遺伝子; 癌; 細胞・組織; ストレス; 生体分子; 胚中心; 細胞; ホジキン病; 転移; 病理診断; がん抑制分子; B細胞; 悪性黒色腫

Antibody response to T cell dependent antigens accompanies somatic hypermutation of immunoglobulin Variable region genes, which needs to be regulated precisely and safely. We studied the role of a molecule named GANP up-regualted in germinal center B cells in the peripheral lymphoid organs. GANP is essential for affinity maturation of the antigen specific B cells. Impairment of GANP function caused lymphomas and mammary gland tumors in mice. We showed that the GANP impairments are associated with tumor development in humans and provided the information regarding spontaneous cancer development during inflammation..

对T细胞依赖性抗原的抗体应答伴随着免疫球蛋白可变区基因的体细胞超突变，其需要被精确且安全地调控。我们研究了外周淋巴器官中生发中心B细胞中一种名为GANP的上调分子的作用。GANP对于抗原特异性B细胞的亲和力成熟是必需的。GANP功能受损可导致小鼠淋巴瘤和乳腺肿瘤。我们发现GANP损伤与人类肿瘤发展相关，并提供了有关炎症期间自发性癌症发展的信息。

项目成果

Functional differences between GANP and THP1 in B cell activation and development.

GANP 和 THP1 在 B 细胞激活和发育中的功能差异。

• 发表时间: 2008
• 作者: Kawazoe T;Tsuge H;Imagawa T;Aki K;Kuramitsu S;Fukui K;Yoshida M.;Kazuhiko Kuwahara;Kuwahara K.
• 通讯作者: Kuwahara K.

mRNA核外輸送分子GANP異常による乳癌発症

mRNA核输出分子GANP异常导致乳腺癌发生

• 发表时间: 2009
• 作者: Matsumoto I.;Kouchi M.;Okimoto K.;Kijima K.;Ueda T.;Hirayama Y.;Inoue T.;Hino O.;阪口薫雄
• 通讯作者: 阪口薫雄

Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity

• DOI: 10.1182/blood-2009-08-236398
• 发表时间: 2010-04-01
• 期刊: BLOOD
• 影响因子: 20.3
• 作者: Mansson, Robert;Zandi, Sasan;Sigvardsson, Mikael
• 通讯作者: Sigvardsson, Mikael

Protein phosphatase subunit G5PR that regulates the JNK-mediated apoptosis signal is essential for the survival of CD4 and CD8 double-positive thymocytes

• DOI: 10.1016/j.molimm.2007.10.028
• 发表时间: 2008-04-01
• 期刊: MOLECULAR IMMUNOLOGY
• 影响因子: 3.6
• 作者: Xing, Yan;Wang, Xiaodan;Sakaguchi, Nobuo
• 通讯作者: Sakaguchi, Nobuo

Characterization of ganp gene abnormality in human breast cancer

人类乳腺癌 ganp 基因异常的特征

• 发表时间: 2007
• 作者: Sakai T;Liu L;Teng X;Ishimaru N;Sakai R;Tran HN;Sano N;Hayashi Y;Kaji R;Fukui K;Kazuhiko Kuwahara;Takashi Sakai;Kazuhiko Kuwahara;Kuwahara K.;Kazuhiko Kuwahara
• 通讯作者: Kazuhiko Kuwahara