Cancer development induced by deregulation of nuclear factors
Cancer development induced by deregulation of nuclear factors
批准号:
17013071
负责人:
NAKAO Mitsuyoshi
金额:
$45.76万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009
中文摘要
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英文摘要
This study focused on investigating the molecular basis of epigenetic cell deregulation in cancer, through analyzing the abnormalities of nuclear factors including methylated DNA binding protein MBD1 and its associated factor MCAF1, CTCF-mediated chromatin insulator, HMGA proteins, SUMOylation of nuclear proteins, and nuclear substructure. These findings strongly contribute to promoting cancer diagnosis and therapy.
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癌のエピジェネティクスと細胞異型の分子基盤
癌症表观遗传学和细胞异型性的分子基础
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Jiang W., Fujii H., Matsumoto T., Ohtsuji N., Tsurumaru M., Hino O., 中尾光善]
通讯作者:
中尾光善
Activation of Sp1-mediated transcription by Rta of Epstein-Barr virus via an interaction with MCAF1.
DOI:
10.1093/nar/gki956
发表时间:
2005
期刊:
Nucleic acids research
影响因子:
14.9
作者:
[Chang LK, Chung JY, Hong YR, Ichimura T, Nakao M, Liu ST]
通讯作者:
Liu ST
The high mobility group protein HMGA1 inhibits retinoblastoma protein-mediated cellular GO arrest.
高迁移率族蛋白 HMGA1 抑制视网膜母细胞瘤蛋白介导的细胞 GO 阻滞。
DOI:
--
发表时间:
2007
期刊:
Cancer Sci. 98
影响因子:
--
作者:
[Ueda, Y., et. al.]
通讯作者:
et. al.
Promyelocytic leukemia protein induces apoptosis due to caspase-8 activation via the repression of NF-kB activation in glioblastoma.
早幼粒细胞白血病蛋白通过抑制胶质母细胞瘤中 NF-kB 的激活,诱导 caspase-8 激活导致细胞凋亡。
DOI:
--
发表时间:
2009
期刊:
Neuro-Oncol. 11
影响因子:
--
作者:
[Terasawa K, Toyota M, Sagae S, Ogi K, Suzuki H, Sonoda T, Akino K, Maruyama R, Nishikawa N, Imai K, Shinohara Y, Saito T, Tokino T, S.Akaboshi, S.Tei, T.Zhao, K.Kuwayama]
通讯作者:
K.Kuwayama
Polycomb group protein-associated chromatin is reproduced in post-mitotic G1 phase and required for S phase progression.
多梳族蛋白相关染色质在有丝分裂后 G1 期复制,是 S 期进展所必需的。
DOI:
--
发表时间:
2008
期刊:
J. Biol. Chem. 283
影响因子:
--
作者:
[T. Aoto, N. Saitoh, Y. Sakamoto, S. Watanabe, M. Nakao]
通讯作者:
M. Nakao
共 61 条
Application of estrogen induced apoptosis in endocrine therapy-resistant breast cancer using Eleanor RNAs as an indicator
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批准号:18K19479
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项目类别:Grant-in-Aid for Challenging Research (Exploratory)
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资助金额:$3.99万
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财政年份:2018
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负责人:NAKAO Mitsuyoshi
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依托单位:
Anti-aging effect of lysine demethylase inhibition and its biomedical application
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批准号:24659152
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
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财政年份:2012
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负责人:NAKAO Mitsuyoshi
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依托单位:
Cellular energy control by lysine demethylation and its therapeutic potentials
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批准号:23659173
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.58万
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财政年份:2011
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负责人:NAKAO Mitsuyoshi
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依托单位:
Multifunction of chromatin insulator and epigenetic regulation
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批准号:22390055
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.9万
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财政年份:2010
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负责人:NAKAO Mitsuyoshi
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依托单位:
SUMO modification and nuclear remodeling in cell development
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批准号:19390078
-
项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.81万
-
财政年份:2007
-
负责人:NAKAO Mitsuyoshi
-
依托单位:
Medical genetic research on molecular basis of epigenetic regulation and human diseases
-
批准号:16209011
-
项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.62万
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财政年份:2004
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负责人:NAKAO Mitsuyoshi
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依托单位:
Development of a new strategy to control gene expression by chromatin conversion
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批准号:13557015
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.27万
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财政年份:2001
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负责人:NAKAO Mitsuyoshi
-
依托单位:
Mechanism of tumorigenesis by abnormal modification and regulation of intracellular molecules
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批准号:13214086
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$22.53万
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财政年份:2000
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负责人:NAKAO Mitsuyoshi
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依托单位:
Structure and function of a imprinting center in the region of human SNRPN gene
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批准号:09672312
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.92万
-
财政年份:1997
-
负责人:NAKAO Mitsuyoshi
-
依托单位:
海外基金