Stromal factors regulating tumor cell motility

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We have identified tumor stroma-derived molecules that upregulate tumor cell motility via cell surface CD44 ; they include low-molecular-weight hyaluronic acid and chondroitin sulfate E. They are produced by the enzymes produced by tumor cells and act on the tumor cells in an autocrine/paracrine manner. We also found that a number of the stroma-derived molecules bind chemokines and that certain combinations of chemokines modulate tumor cell motility, implying that certain stroma-derived molecules and chemokines upregulate tumor cell motility synergistically.