Generation of a new mouse model for transplantation of human cells by utilizing an anti-IL-2 receptor beta chain monoclonal antibody

利用单次静脉注射抗IL-2受体β链单克隆抗体（anti-IL-2Rbeta）可在体内长期特异性清除自然杀伤（NK）细胞这一事实，我们试图建立一种易于移植各种类型人类细胞的小鼠模型。我们发现，向SCID小鼠注射抗il - 2rbeta可诱导NK细胞的长期消除，从而产生T-、B-和NK缺陷小鼠。在未治疗的SCID小鼠中通常不能生长的ATL细胞在这种抗体治疗的nk缺陷SCID小鼠中生长良好，这提出了一种有趣的可能性，即这种体内模型可用于筛选和测试抗ATL候选药物的功效。该抗体也可能有利于SCID-Hu的产生。

By takeing advantage of the fact that natural killer (NK) cells can be eliminated specifically for long-term in vivo by a single i.p. injection of monoclonal antibody against IL-2 receptor beta chain (anti-IL-2Rbeta), we attempted to generate a mouss model in which various types of human cells can be readily transplanted. We found that injection of the anti-IL-2Rbeta into SCID mice induces long-term elimination of NK cells, thus generating T-, B- and NK-deficient mice. ATL cells that do not normally grow in untreated SCID mice did grow well in such antibody-treated NK-deficient SCID mice, raising an interesting possibility that this in vivo model can be used for screening and testing the efficacy of anti-ATL drug candidates. This antibody may be also be beneficial for generation of SCID-Hu.