Functional analysis of the C-treminal frangment of membrane-anchored growth factors

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We analyzed the function of C-terminal fragment (CTF) signals which are evoked by the shedding of a representative membrane-anchored growth factor proHB-EGF. We found that (1) the CTF of proHB-EGF was internalized into cytosol by endocytosis and localized at the innernuclear membrane by retrograde vesicle transport, (2) the CTF regulated several gene expression essential for cell growth promotion by interacting with and regulating gene repressors, and (3) the CTF signal was constitutively active in some tumor cell lines.