The risk evaluation and chemoprevention of the prostate cancer

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The patients with prostate cancer were proved to have low equol-producing ability to metabolize daidzein to equol. For the first time, by the stool culture of the equol-producing volunteers persons, we isolated gram-positive bacilli "NATTS strain" which was a non-spore-forming rod bacterium with high ability to convert daidzein to equol. By the double-blind study of the high risk persons for prostate cancer, the prostate cancer incidence of the isoflavone group was lower than the placebo group. Based on this study, we will make a prostate cancer chemoprevention strategy in the future.