The risk evaluation and chemoprevention of the prostate cancer

前列腺癌的风险评估和化学预防

• 批准号: 17015006
• 负责人: AKAZA Hideyuki
• 金额: $ 51.65万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17015006/
• 关键词: がん; ゲノム; 食品; 大豆イソフラボン; 細菌; 癌

The patients with prostate cancer were proved to have low equol-producing ability to metabolize daidzein to equol. For the first time, by the stool culture of the equol-producing volunteers persons, we isolated gram-positive bacilli "NATTS strain" which was a non-spore-forming rod bacterium with high ability to convert daidzein to equol. By the double-blind study of the high risk persons for prostate cancer, the prostate cancer incidence of the isoflavone group was lower than the placebo group. Based on this study, we will make a prostate cancer chemoprevention strategy in the future.

前列腺癌患者代谢大豆黄酮为雌马酚的能力较低。本文首次从产马酚志愿者粪便培养中分离出革兰氏阳性杆菌NATTS菌株，这是一种不产孢子的杆状细菌，具有将大豆苷元转化为马酚的能力。通过对前列腺癌高危人群的双盲研究，异黄酮组前列腺癌发病率低于安慰剂组。在此基础上，我们将制定前列腺癌的化学预防策略。

项目成果

Fate of seminal vesicles and prostate after medical castrati on : how long is the optimal duration of neoadjuvant treatment for prostate cancer before radiation

药物去势后精囊和前列腺的命运：放射前前列腺癌新辅助治疗的最佳持续时间是多长

• 发表时间: 2008
• 期刊: Urology 72
• 作者: Furuya R;et.al.
• 通讯作者: et.al.

Downregulation of thymosin beta4 expression by androgen in prostate cancer LNCaP cells.

前列腺癌 LNCaP 细胞中雄激素下调胸腺素 β4 表达。

• 发表时间: 2008
• 期刊: J Androl 29(2)
• 作者: Iguchi K;et. al.
• 通讯作者: et. al.

Change in International Prostate Symptom Score, prostate-specific antigen and prostate volume in patients with benign prostatic hyperplasia followed longitudinally.

纵向跟踪良性前列腺增生患者国际前列腺症状评分、前列腺特异性抗原和前列腺体积的变化。

• 发表时间: 2007
• 期刊: Int J Urol 14(4)
• 作者: Tsukamoto T;et. al.
• 通讯作者: et. al.

The establishment of two paclitaxel-resistant prostate cancer cell lines and the mechanisms of paclitaxl resistance with two cell lines.

两种紫杉醇耐药前列腺癌细胞系的建立及两种细胞系的紫杉醇耐药机制。

• 发表时间: 2007
• 期刊: Prostate 67(9)
• 作者: Tadeda M;et. al.
• 通讯作者: et. al.

Murine androgen-independent neuroendocrine carcinoma promotes metastasis of human prostate carcer cell line LNCaP

小鼠雄激素非依赖性神经内分泌癌促进人前列腺癌细胞系LNCaP的转移

• 发表时间: 2006
• 期刊: Prostate 66
• 作者: Uchida K.;et al.
• 通讯作者: et al.