Investigation of the male predominance of bladder cancer

要分析人类起源中的男性荷尔蒙的参与情况。我们管理员的Gonadotropin-释放激素模拟（LH·RH模拟）将雄性大鼠地方的甲状腺瘤实验模型从N-butyl-N-（4-羟基）硝基胺（BBN）中诱导，并进一步研究了雄性激素动力学和遗传比率之间的关系。实验1：雄性大鼠pituitary-testicular axis诱导的LH·RH模拟被测试的LH·RH模拟。血清LH、FSH和睾丸激素水平显示LH/RH模拟仓库（1毫克/身体重量，每月）在一天后注射和减少。在LH·RH模拟注射后一周内，睾丸-类固醇成为一种定位水平。BBN没有影响Pituitary-Testicular axis和LH·RH模拟的行动。实验2：我们在5个小组中分成了143只雄性Wistar老鼠。Group 1：0. 05%BBN had been administered for 8 weeks。Group 2：0. 05%BBN and LH·RH analogue for 8 weeks。Group 3：0. 05%BBN for 8 weeks and then LH·RH analogue for 16 weeks。Group 4：0. 05%BBN for 8 weeks and at the same time LH·RH analogue for the overall process。第5组：0.05%BBN在8周后携带器官。脑结构学是由所有老鼠在24周后的实验中开始的，因为实验在历史上开始了，BBN对睾丸激素抑制的大鼠叶片的定量化。LH·RH模拟仓库的铸造、外科铸造或医学铸造的方式，可能在不同的方式中采取行动，以抑制bladder carcinogenesis。以上的现象可能会在黑曲霉-皮图库-测试轴上指示调节性系统。当LH·RH模拟被管理在bladder carcinogenesis的促进阶段，需要进一步的研究来清除对bladder carcinogenesis的增强的抑制的LH·RH模拟。

To analyze the participation of male hormone in the genesis of urinary bladder carcinoma. We administered gonadotropin-releasing hormone analogue (LH・RH analogue) to the experimental model of male rats where carcinoma is induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN),and further examined the relation between the change of male hormone kinetics and the genesis ratio.Experiment 1: the changes of male rat pituitary-testicular axis induced by a LH・RH analogue were examined. Serum LH, FSH and testosterone levels showed their peaks one day after the LH・RH analogue depot (1 mg/body weight, monthly) injection and decreased afterwards. testo-sterone became castration level one week after the LH・RH analogue injection. BBN did not influence pituitary-testicular axis and action of the LH・RH analogue.Experiment 2: We divided 143 male Wistar rats of 9 weeks into 5 groups. Group 1: 0.05% BBN had been administered for 8 weeks. Group 2: 0.05% BBN and LH・RH analogue for 8 weeks. Group 3: 0.05% BBN for 8 weeks and then LH・RH analogue for 16 weeks. Group 4: 0.05% BBN for 8 weeks and at the same time LH・RH analogue for the overall process. Group 5: 0.05% BBN for 8 weeks after carrying out orchidectomy. Cystectomy was conducted on all of the rats 24 weeks after the experiment had started so as to examine histologically.Diminution of testosterone inhibited rat bladder carcinogenesis induced by BBN. The way of castration, surgical castration or medical castration by LH・RH analogue depot, might act in a different way to inhibit the bladder carcinogenesis. The above phenomenon may indicate the regulatory system in the hypothalamus-pituitary-testicular axis on the bladder carcinogenesis. The inhibition was most significant when LH・RH analogue was administered in the promotion phase of bladder carcinogenesis.Further studies are required to make clear the augmented inhibition of LH・RH analogue on bladder carcinogenesis.