Bio-chemoprevention of recurrenceof superficial bladder cancer-Mechanisms of inhibition by Lactobacillus casei preparation (BLP) on bladder carcinogenesis-

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It is reported that BLP (p.o.administration) prevents recurrence of superficial bladder cancer after TUR-Bt. In this study, we have investigated mechanisms of the preventive effects of BLP.Seven kinds of lacto-bacilli were tested for its inhibitory ability on carcinogenic promotion using concanavalin-A agglutinating method. Half of bacilli tested including BLP showed the inhibitory effect on bladder carcinogenesis. It is important to investigate the viability in the intestine and other biological characteristics of the lacto-bacilli tested.Tabaco smoking is a major risk factor for bladder carcinogenesis in human, which is known to excrete mutagens in urine. In our preliminary investigation, BLP clearly decreased the mutagenic products in the urine (TA98, S9+) in some volunteers but not in all. BLP which grow in the intestine might contribute to inhibit metabolization of mutagenic (carcinogenic) substances as a result of alternating microflora in intestine. (ex : reducing nitroso-urea producing bacterias).We have hypothesized two mechanisms of recurrence of superficial bladder cancer ; one is true recurrence and the other second primary cancer. The second primary cancer may arise from initiated cells, which persist for long time in the bladder epithelium of the patients with bladder cancer and grow to cancer by some promoting influences. From our investigations, BLP is promising to inhibit the second primary cancer by reducing the promoting influences.