Bio-chemoprevention of recurrenceof superficial bladder cancer-Mechanisms of inhibition by Lactobacillus casei preparation (BLP) on bladder carcinogenesis-
浅表性膀胱癌复发的生物化学预防-干酪乳杆菌制剂(BLP)抑制膀胱癌发生的机制-
基本信息
- 批准号:07807148
- 负责人:
- 金额:$ 1.41万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:1995
- 资助国家:日本
- 起止时间:1995 至 1997
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
It is reported that BLP (p.o.administration) prevents recurrence of superficial bladder cancer after TUR-Bt. In this study, we have investigated mechanisms of the preventive effects of BLP.Seven kinds of lacto-bacilli were tested for its inhibitory ability on carcinogenic promotion using concanavalin-A agglutinating method. Half of bacilli tested including BLP showed the inhibitory effect on bladder carcinogenesis. It is important to investigate the viability in the intestine and other biological characteristics of the lacto-bacilli tested.Tabaco smoking is a major risk factor for bladder carcinogenesis in human, which is known to excrete mutagens in urine. In our preliminary investigation, BLP clearly decreased the mutagenic products in the urine (TA98, S9+) in some volunteers but not in all. BLP which grow in the intestine might contribute to inhibit metabolization of mutagenic (carcinogenic) substances as a result of alternating microflora in intestine. (ex : reducing nitroso-urea producing bacterias).We have hypothesized two mechanisms of recurrence of superficial bladder cancer ; one is true recurrence and the other second primary cancer. The second primary cancer may arise from initiated cells, which persist for long time in the bladder epithelium of the patients with bladder cancer and grow to cancer by some promoting influences. From our investigations, BLP is promising to inhibit the second primary cancer by reducing the promoting influences.
据报道,BLP(口服给药)可预防TUR-Bt后浅表性膀胱癌复发。本研究采用刀豆球蛋白-A凝集法检测了7种乳杆菌对BLP致癌促进作用的抑制作用,并对BLP的致癌促进作用机制进行了初步探讨。包括BLP在内的半数细菌对膀胱癌的发生有抑制作用。研究乳酸杆菌在肠道中的存活能力和其他生物学特性是非常重要的。烟草吸烟是人类膀胱癌发生的主要危险因素,已知烟草吸烟可通过尿液排出致突变物。在我们的初步研究中,BLP明显降低了一些志愿者尿液中的致突变产物(TA 98,S9+),但并非所有志愿者。BLP在肠道内生长,可能由于肠道内微生物菌群的交替而有助于抑制致突变(致癌)物质的代谢。(ex:减少亚硝基尿素产生细菌)。我们假设了表浅膀胱癌复发的两种机制;一种是真正的复发,另一种是第二原发性癌症。第二原发癌可能起源于膀胱癌患者膀胱上皮中的原始细胞,这些原始细胞在膀胱癌患者膀胱上皮中长期存在,并在某些促进因素的作用下生长成癌。从我们的研究来看,BLP有希望通过减少促进作用来抑制第二原发癌。
项目成果
期刊论文数量(21)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Shimazui T.Akaza.H et al.: "Prognostic value of cadherin-associated molecules in bladder tumors" Cancer Res. 56. 4154-4158 (1996)
Shimazui T.Akaza.H 等人:“膀胱肿瘤中钙粘蛋白相关分子的预后价值”Cancer Res。
- DOI:
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- 影响因子:0
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- 通讯作者:
Tsutsumi M., Akaza H.et al.: "Correlation of atleic loss of the p53 gene and tumor grade stage,and malignant progression in bladder cancer." Int.J.Urol.4(1). 74-78 (1997)
Tsutsumi M.、Akaza H.et al.:“p53 基因无闭锁丢失与肿瘤分级阶段以及膀胱癌恶性进展的相关性。”
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- 影响因子:0
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Lamm DL, Akaza H et al.: "Intraiesical chemotherapy and immunotheropy : how do we assess their effectiveness and what are their limitations and uses" Int.J.Urol. 2(suppl). suppl 2 23-35 (1995)
Lamm DL、Akaza H 等人:“子宫内化疗和免疫疗法:我们如何评估它们的有效性以及它们的局限性和用途” Int.J.Urol。
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- 影响因子:0
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Akaza H.et.al.: "Evaluation of urinary NMP-22 as a diagnostic marker for urothelial cancer." Jap.J.Cancer and Chemother. 24 (7). 837-842 (1997)
Akaza H.et.al.:“评估尿液 NMP-22 作为尿路上皮癌的诊断标志物。”
- DOI:
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- 影响因子:0
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- 通讯作者:
Shimazui.T., Agaza H.et.al.: "Prognostic value of cadherin-associated molecules in bladder tumors" Cancer Res.56. 4154-4158 (1996)
Shimzui.T.、Agaza H.et.al.:“膀胱肿瘤中钙粘蛋白相关分子的预后价值”Cancer Res.56。
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AKAZA Hideyuki其他文献
AKAZA Hideyuki的其他文献
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{{ truncateString('AKAZA Hideyuki', 18)}}的其他基金
The risk evaluation and chemoprevention of the prostate cancer
前列腺癌的风险评估和化学预防
- 批准号:
17015006 - 财政年份:2005
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
Effect on the carcinogenesis of male rat bladder cancer of antiandrogen and 5_<alpha>-reductase inhibitor
抗雄激素及5_α-还原酶抑制剂对雄性大鼠膀胱癌癌变的影响
- 批准号:
05671298 - 财政年份:1993
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
Investigation of the male predominance of bladder cancer
膀胱癌男性多发的调查
- 批准号:
62570718 - 财政年份:1987
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
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