Integrative genomics and epigenomics for personalized cancer medicine

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Innovative techniques for detection of genomic and epigenomic aberrations underlying the pathogenesis have been developed and using those techniques numerous cancer-related genes have been successfully identified during the course of the research program. In particular, we identified 10 candidate oncogenes including DUSP26 and SMYD2 up-regulated due to gene amplification, and 10 candidate tumor suppressor genes including DBC1 and PCDH17. Furthermore four tumor-suppressor microRNAs, miR-13 and miR-193a, or miR-124 and miR-203, epigenetically silenced, were successfully identified in oral cancer or hepatocellular carcinoma, respectively.