Integrative genomics and epigenomics for personalized cancer medicine

个性化癌症医学的综合基因组学和表观基因组学

• 批准号: 17015012
• 负责人: INAZAWA Johji
• 金额: $ 74.56万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17015012/
• 关键词: がん; ゲノム; エピゲノム; マイクロアレイ; がん遺伝子; がん抑制遺伝子; マイクロRNA; CGH; 個性診断; 分子標的治療; CGHアレイ; DNAメチル化; GhIP法; BAMCA法; アレイCGH; ChIP法

Innovative techniques for detection of genomic and epigenomic aberrations underlying the pathogenesis have been developed and using those techniques numerous cancer-related genes have been successfully identified during the course of the research program. In particular, we identified 10 candidate oncogenes including DUSP26 and SMYD2 up-regulated due to gene amplification, and 10 candidate tumor suppressor genes including DBC1 and PCDH17. Furthermore four tumor-suppressor microRNAs, miR-13 and miR-193a, or miR-124 and miR-203, epigenetically silenced, were successfully identified in oral cancer or hepatocellular carcinoma, respectively.

已经开发了用于检测发病机制背后的基因组和表观基因组畸变的创新技术，并且使用这些技术，在研究计划的过程中已经成功地鉴定了许多癌症相关基因。特别是，我们确定了10个候选癌基因，包括DUSP 26和SMYD 2由于基因扩增而上调，以及10个候选肿瘤抑制基因，包括DBC 1和PCDH 17。此外，在口腔癌或肝细胞癌中分别成功鉴定了表观遗传学沉默的四种肿瘤抑制microRNA，miR-13和miR-193 a，或miR-124和miR-203。

项目成果

Lysosomal-associated protein multispanning transmembrane 5 gene (LAPTM5) is associated with spontaneous regression of neuroblastomas.

• DOI: 10.1371/journal.pone.0007099
• 发表时间: 2009-09-29
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Inoue J;Misawa A;Tanaka Y;Ichinose S;Sugino Y;Hosoi H;Sugimoto T;Imoto I;Inazawa J
• 通讯作者: Inazawa J

Overexpressed Skp2 within 5p amplification detected by array‐based comparative genomic hybridization is associated with poor prognosis of glioblastomas

• DOI: 10.1111/j.1349-7006.2005.00099.x
• 发表时间: 2005-10
• 期刊: Cancer Science
• 影响因子: 5.7
• 作者: K. Saigusa;N. Hashimoto;H. Tsuda;S. Yokoi;M. Maruno;T. Yoshimine;M. Aoyagi;Kikuo Ohno;I. Imoto;J. Inazawa

小頭症と小脳脳幹部低形成を伴う発達遅滞12例におけるCASK遺伝子の解析

12例小头畸形发育迟缓并小脑脑干发育不全患者CASK基因分析

• 发表时间: 2009
• 作者: 林深;岡本伸彦;水野誠司;小野正恵;小崎里華;奥山虎之;知念安紹;蒔田芳男;羽田明;井本逸勢;稲澤譲治
• 通讯作者: 稲澤譲治

DEK oncoprotein regulates transcriptional modifiers and sustains tumor initiation activity in high-grade neuroendocrine carcinoma of the lung

• DOI: 10.1038/onc.2010.217
• 发表时间: 2010-08-01
• 期刊: ONCOGENE
• 影响因子: 8
• 作者: Shibata, T.;Kokubu, A.;Hirohashi, S.
• 通讯作者: Hirohashi, S.

Non-incidental coamplification of Myc and ERBB2, and Myc and BGFR, in gastric adenocarcinomas.

胃腺癌中 Myc 和 ERBB2、Myc 和 BGFR 的非偶然共扩增。

• 发表时间: 2007
• 期刊: Modern Pathology 20
• 作者: Mitsui F;Inazawa J;et. al.
• 通讯作者: et. al.