Development of personalized methods for the diagnosis and treatment for bone and soft tissue sarcomas

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Spindle cell sarcoma is a subtype of bone and soft tissue sarcomas, for which definite diagnoses are difficult in some cases, and no effective drugs are available. We have performed genome-wide expression profiling of spindle cell sarcomas, and found that spindle cell sarcomas were classified based on gene expression profiles, which was different from pathological classification. We also found that anti-FZD10 antibody, inhibitor of FGF receptors, and retinoic acid are candidates for molecular target therapy for synovial sarcoma. Finally, we found a novel molecule, of which the expression was closely associated with prognosis of spindle cell sarcomas irrespective with pathological diagnoses.