Basic study on cancer cell selective radiotherapy by particle beam

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Clinical research of cell selective therapy, BNCT, by using neutrons from a nuclear reactor was progressed. And, BNCT to liver cancer with multiple lesions and malignant pleural mesothelioma was performed first in the world. Through the researches on technique for selective delivery of a boron compound, the improvement of the boron distribution in a tumor and the increase in boron concentration was achieved in parallel. They include an injection of boron compound to a tumor feeding artery, Avastin (tumor blood vessel inhibitor) medication and preceded X-rays irradiation, etc. The cyclotron based neutron source as an alternative of nuclear reactor has been developed, and physical/biological characteristic of a neutron beam was examined, and the ability for clinical use was proved.