Basic study on cancer cell selective radiotherapy by particle beam

粒子束癌细胞选择性放射治疗的基础研究

基本信息

  • 批准号:
    17016037
  • 负责人:
  • 金额:
    $ 28.8万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research on Priority Areas
  • 财政年份:
    2005
  • 资助国家:
    日本
  • 起止时间:
    2005 至 2009
  • 项目状态:
    已结题

项目摘要

Clinical research of cell selective therapy, BNCT, by using neutrons from a nuclear reactor was progressed. And, BNCT to liver cancer with multiple lesions and malignant pleural mesothelioma was performed first in the world. Through the researches on technique for selective delivery of a boron compound, the improvement of the boron distribution in a tumor and the increase in boron concentration was achieved in parallel. They include an injection of boron compound to a tumor feeding artery, Avastin (tumor blood vessel inhibitor) medication and preceded X-rays irradiation, etc. The cyclotron based neutron source as an alternative of nuclear reactor has been developed, and physical/biological characteristic of a neutron beam was examined, and the ability for clinical use was proved.
通过使用来自核反应堆的中子的细胞选择性治疗(BNCT)的临床研究取得进展。其中,肝癌多发病灶和恶性胸膜间皮瘤的BNCT在国际上尚属首例。通过对硼化合物的选择性递送技术的研究,同时实现了硼在肿瘤中分布的改善和硼浓度的增加。它们包括硼化合物注射到肿瘤供血动脉,Avastin(肿瘤血管抑制剂)药物和之前的X射线照射,等回旋加速器为基础的中子源作为核反应堆的替代品已经开发出来,和物理/生物学特性的中子束进行了检查,并证明了临床使用的能力。

项目成果

期刊论文数量(61)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Analysis of Boron Distribution In Vivo for Boron Neutron Capture Therapy using Two Different Boron Compounds by Secondary Ion Mass Spectrometry.
通过二次离子质谱分析使用两种不同硼化合物进行硼中子捕获疗法的体内硼分布。
  • DOI:
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    0
  • 作者:
    K. Yokoyama;S. Miyatake(10名中2番);M. Kirihata(10名中8番);K. Ono(10名中9番)
  • 通讯作者:
    K. Ono(10名中9番)
Improvement of the tumor-suppressive effect of boron neutron capture therapy for amelanotic melanoma by intra-tumoral infection of the tyrosinase gene
通过酪氨酸酶基因的瘤内感染提高硼中子捕获疗法对无色素性黑色素瘤的抑瘤效果
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    N.Morita;J.Hiratsuka;H.Kondoh;K.Ono;T.Harada;et al.
  • 通讯作者:
    et al.
Improvement of effect on the depth-dose distribution by CSF drainage and air infusion of a tumour removed cavity in boron neutron capture therapy for malignat brain tumours
硼中子俘获治疗恶性脑肿瘤肿瘤切除腔内脑脊液引流和注气改善深度剂量分布的效果
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Y.Sakurai;K.Ono;他2名
  • 通讯作者:
    他2名
Evaluation of hypoxia-specific cytotoxic bioreductive agent-sodium borocaptate-10B conjugates as 10B-carriers in boron neutron capture therapy.
  • DOI:
    10.1007/bf02493275
  • 发表时间:
    2006-02-01
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Masunaga, Shin-Ichiro;Nagasawa, Hideko;Ono, Koji
  • 通讯作者:
    Ono, Koji
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ONO Koji其他文献

ONO Koji的其他文献

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{{ truncateString('ONO Koji', 18)}}的其他基金

On the Theory of "Governance Formation" from the Viewpoint of " Wicked Problems"
从“棘手问题”看“治理形态”理论
  • 批准号:
    15K03272
  • 财政年份:
    2015
  • 资助金额:
    $ 28.8万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
application of high resolution arufa-autoradiography for analysing micro-distribution of B-compund in tissues and its BNCT effects
应用高分辨率阿鲁法放射自显影分析B化合物在组织中的微观分布及其BNCT效应
  • 批准号:
    26670557
  • 财政年份:
    2014
  • 资助金额:
    $ 28.8万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Study on the correlation of the personnel system and social awareness in the Ming and Qing Dynasties
明清人事制度与社会意识的相关性研究
  • 批准号:
    22720261
  • 财政年份:
    2010
  • 资助金额:
    $ 28.8万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Development of a new method to analyzethe micro-distribution of 10B in tissues and its application to BNCT research
组织中10B微观分布分析新方法的建立及其在BNCT研究中的应用
  • 批准号:
    22240091
  • 财政年份:
    2010
  • 资助金额:
    $ 28.8万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
A Basic Study of Personnel System and Ideas about that Practical Use in the Pre-modern China
近代中国人事制度及其运用理念的基础研究
  • 批准号:
    19720178
  • 财政年份:
    2007
  • 资助金额:
    $ 28.8万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Analysis of Political Transformation in Advanced Societies by Constructivist Political Theory : Through Comparison among Results of General Elections in Great Britain, Japan, and Germany
用建构主义政治理论分析先进社会的政治转型——通过英、日、德大选结果比较
  • 批准号:
    18330024
  • 财政年份:
    2006
  • 资助金额:
    $ 28.8万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Interaction between Theory and Praxis within the Process of Political Transformation among Advanced Democracies
先进民主国家政治转型过程中理论与实践的互动
  • 批准号:
    15530088
  • 财政年份:
    2003
  • 资助金额:
    $ 28.8万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Comparative Theoretical Analysis about the Political Transformation in Contemporary Advanced Democracies
当代先进民主国家政治转型的比较理论分析
  • 批准号:
    13620086
  • 财政年份:
    2001
  • 资助金额:
    $ 28.8万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Basic research for Gd-NCT
Gd-NCT基础研究
  • 批准号:
    04454296
  • 财政年份:
    1992
  • 资助金额:
    $ 28.8万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
Individualization of Radiotherapy by Micronucleus Test
通过微核测试实现个体化放射治疗
  • 批准号:
    01570588
  • 财政年份:
    1989
  • 资助金额:
    $ 28.8万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)

相似海外基金

Creation of highly reactive boron compounds by thorough utilization of vacant orbital
充分利用空轨道制备高反应性硼化合物
  • 批准号:
    17H01191
  • 财政年份:
    2017
  • 资助金额:
    $ 28.8万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Development of an analytical method for in vivo individual concentration determination and the confirmation of pharmacokinetics properties for the two BNCT boron compounds
开发两种 BNCT 硼化合物体内个体浓度测定和药代动力学特性确认的分析方法
  • 批准号:
    16K01443
  • 财政年份:
    2016
  • 资助金额:
    $ 28.8万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Free Radical and Radiation Chemistry with Boron Compounds
硼化合物的自由基和辐射化学
  • 批准号:
    464593-2014
  • 财政年份:
    2014
  • 资助金额:
    $ 28.8万
  • 项目类别:
    University Undergraduate Student Research Awards
The Use of Environmentally-Benign Boron Compounds
使用环境友好的硼化合物
  • 批准号:
    467006-2014
  • 财政年份:
    2014
  • 资助金额:
    $ 28.8万
  • 项目类别:
    Engage Grants Program
Switchable luminescent boron compounds
可切换发光硼化合物
  • 批准号:
    399633-2010
  • 财政年份:
    2010
  • 资助金额:
    $ 28.8万
  • 项目类别:
    University Undergraduate Student Research Awards
Dehydrocoupling Reactions of Boron Compounds via a Transition Metal. BoraneσComplex
硼化合物通过过渡金属硼烷σ配合物的脱氢偶联反应。
  • 批准号:
    21550056
  • 财政年份:
    2009
  • 资助金额:
    $ 28.8万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Organic and catalysis chemistry based on low-valent boron compounds
基于低价硼化合物的有机和催化化学
  • 批准号:
    21685006
  • 财政年份:
    2009
  • 资助金额:
    $ 28.8万
  • 项目类别:
    Grant-in-Aid for Young Scientists (A)
Transition - metal catalyzed addition of boron compounds to imines and iminium ions
过渡金属催化硼化合物与亚胺和亚胺离子的加成
  • 批准号:
    334115-2006
  • 财政年份:
    2008
  • 资助金额:
    $ 28.8万
  • 项目类别:
    Postgraduate Scholarships - Doctoral
Simultaneous sampling method of toxic exhaust gas and gaseous boron compounds in emission gas using a sampler installed inside of stack (Type-1 sampler).
使用安装在烟囱内部的采样器(1 型采样器)对有毒废气和排放气体中的气态硼化合物进行同时采样的方法。
  • 批准号:
    20510083
  • 财政年份:
    2008
  • 资助金额:
    $ 28.8万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Transition - metal catalyzed addition of boron compounds to imines and iminium ions
过渡金属催化硼化合物与亚胺和亚胺离子的加成
  • 批准号:
    334115-2006
  • 财政年份:
    2007
  • 资助金额:
    $ 28.8万
  • 项目类别:
    Postgraduate Scholarships - Doctoral
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