Basic study on cancer cell selective radiotherapy by particle beam

粒子束癌细胞选择性放射治疗的基础研究

• 批准号: 17016037
• 负责人: ONO Koji
• 金额: $ 28.8万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17016037/
• 关键词: BNCT; 硼素化合物; 中性子; 治療計画システム; 放射線影響; ホウ素中性子捕捉療法; 放射線口腔死; 骨髄影響; BPA; RBE; サイクロトロン; 原子炉; BSH; 蛍光光度測定; 中皮腫; 悪性脳腫瘍; 悪性髄膜腫; 再発頭頸部癌; 悪性中皮腫; 経動脈投与; 中性子捕捉療法; 線量分布; 肺癌; 肝臓癌

Clinical research of cell selective therapy, BNCT, by using neutrons from a nuclear reactor was progressed. And, BNCT to liver cancer with multiple lesions and malignant pleural mesothelioma was performed first in the world. Through the researches on technique for selective delivery of a boron compound, the improvement of the boron distribution in a tumor and the increase in boron concentration was achieved in parallel. They include an injection of boron compound to a tumor feeding artery, Avastin (tumor blood vessel inhibitor) medication and preceded X-rays irradiation, etc. The cyclotron based neutron source as an alternative of nuclear reactor has been developed, and physical/biological characteristic of a neutron beam was examined, and the ability for clinical use was proved.

利用核反应堆中子进行细胞选择性治疗（BNCT）的临床研究取得进展。其中，全球首次对多发性肝癌和恶性胸膜间皮瘤进行BNCT。通过对硼化合物选择性递送技术的研究，同时实现了硼在肿瘤中分布的改善和硼浓度的增加。它们包括向肿瘤供血动脉注射硼化合物、阿瓦斯汀（肿瘤血管抑制剂）药物和预先X射线照射等。作为核反应堆替代品的基于回旋加速器的中子源已经开发出来，并检查了中子束的物理/生物特性，并证明了临床使用的能力。

项目成果

Improvement of the tumor-suppressive effect of boron neutron capture therapy for amelanotic melanoma by intra-tumoral infection of the tyrosinase gene

通过酪氨酸酶基因的瘤内感染提高硼中子捕获疗法对无色素性黑色素瘤的抑瘤效果

• 发表时间: 2006
• 期刊: Cancer Res. 66・7
• 作者: N.Morita;J.Hiratsuka;H.Kondoh;K.Ono;T.Harada;et al.
• 通讯作者: et al.

Improvement of effect on the depth-dose distribution by CSF drainage and air infusion of a tumour removed cavity in boron neutron capture therapy for malignat brain tumours

硼中子俘获治疗恶性脑肿瘤肿瘤切除腔内脑脊液引流和注气改善深度剂量分布的效果

• 发表时间: 2006
• 期刊: Phys.Med.Biol. 51
• 作者: Y.Sakurai;K.Ono;他2名
• 通讯作者: 他2名

Analysis of Boron Distribution In Vivo for Boron Neutron Capture Therapy using Two Different Boron Compounds by Secondary Ion Mass Spectrometry.

通过二次离子质谱分析使用两种不同硼化合物进行硼中子捕获疗法的体内硼分布。

• 发表时间: 2007
• 期刊: Radiat. Res. 167
• 作者: K. Yokoyama;S. Miyatake(10名中2番);M. Kirihata(10名中8番);K. Ono(10名中9番)
• 通讯作者: K. Ono(10名中9番)

Modified boron neutron capture therapy for malignant gliomas performed using epithermal neutron and two boron compounds with different accumulation mechanisms: an efficacy study based on findings on neuroimages

• DOI: 10.3171/jns.2005.103.6.1000
• 发表时间: 2005-12-01
• 期刊: JOURNAL OF NEUROSURGERY
• 影响因子: 4.1
• 作者: Miyatake, SI;Kawabata, S;Ono, K
• 通讯作者: Ono, K

Linkage of the irradiation technique and dose-estimation technique in boron neutron capture therapy

硼中子俘获疗法中照射技术和剂量估计技术的联系

• 发表时间: 2005
• 作者: Hirai M;Kadowaki N;Uchiyama T;et.al.;櫻井良憲
• 通讯作者: 櫻井良憲