Basic study on cancer cell selective radiotherapy by particle beam

粒子束癌细胞选择性放射治疗的基础研究

• 批准号: 17016037
• 负责人: ONO Koji
• 金额: $ 28.8万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17016037/
• 关键词: BNCT; 硼素化合物; 中性子; 治療計画システム; 放射線影響; ホウ素中性子捕捉療法; 放射線口腔死; 骨髄影響; BPA; RBE; サイクロトロン; 原子炉; BSH; 蛍光光度測定; 中皮腫; 悪性脳腫瘍; 悪性髄膜腫; 再発頭頸部癌; 悪性中皮腫; 経動脈投与; 中性子捕捉療法; 線量分布; 肺癌; 肝臓癌

Clinical research of cell selective therapy, BNCT, by using neutrons from a nuclear reactor was progressed. And, BNCT to liver cancer with multiple lesions and malignant pleural mesothelioma was performed first in the world. Through the researches on technique for selective delivery of a boron compound, the improvement of the boron distribution in a tumor and the increase in boron concentration was achieved in parallel. They include an injection of boron compound to a tumor feeding artery, Avastin (tumor blood vessel inhibitor) medication and preceded X-rays irradiation, etc. The cyclotron based neutron source as an alternative of nuclear reactor has been developed, and physical/biological characteristic of a neutron beam was examined, and the ability for clinical use was proved.

通过使用来自核反应堆的中子的细胞选择性治疗（BNCT）的临床研究取得进展。其中，肝癌多发病灶和恶性胸膜间皮瘤的BNCT在国际上尚属首例。通过对硼化合物的选择性递送技术的研究，同时实现了硼在肿瘤中分布的改善和硼浓度的增加。它们包括硼化合物注射到肿瘤供血动脉，Avastin（肿瘤血管抑制剂）药物和之前的X射线照射，等回旋加速器为基础的中子源作为核反应堆的替代品已经开发出来，和物理/生物学特性的中子束进行了检查，并证明了临床使用的能力。

项目成果

Analysis of Boron Distribution In Vivo for Boron Neutron Capture Therapy using Two Different Boron Compounds by Secondary Ion Mass Spectrometry.

通过二次离子质谱分析使用两种不同硼化合物进行硼中子捕获疗法的体内硼分布。

• 发表时间: 2007
• 期刊: Radiat. Res. 167
• 作者: K. Yokoyama;S. Miyatake(10名中2番);M. Kirihata(10名中8番);K. Ono(10名中9番)
• 通讯作者: K. Ono(10名中9番)

Improvement of the tumor-suppressive effect of boron neutron capture therapy for amelanotic melanoma by intra-tumoral infection of the tyrosinase gene

通过酪氨酸酶基因的瘤内感染提高硼中子捕获疗法对无色素性黑色素瘤的抑瘤效果

• 发表时间: 2006
• 期刊: Cancer Res. 66・7
• 作者: N.Morita;J.Hiratsuka;H.Kondoh;K.Ono;T.Harada;et al.
• 通讯作者: et al.

Improvement of effect on the depth-dose distribution by CSF drainage and air infusion of a tumour removed cavity in boron neutron capture therapy for malignat brain tumours

硼中子俘获治疗恶性脑肿瘤肿瘤切除腔内脑脊液引流和注气改善深度剂量分布的效果

• 发表时间: 2006
• 期刊: Phys.Med.Biol. 51
• 作者: Y.Sakurai;K.Ono;他2名
• 通讯作者: 他2名

Modified boron neutron capture therapy for malignant gliomas performed using epithermal neutron and two boron compounds with different accumulation mechanisms: an efficacy study based on findings on neuroimages

• DOI: 10.3171/jns.2005.103.6.1000
• 发表时间: 2005-12-01
• 期刊: JOURNAL OF NEUROSURGERY
• 影响因子: 4.1
• 作者: Miyatake, SI;Kawabata, S;Ono, K
• 通讯作者: Ono, K

Evaluation of hypoxia-specific cytotoxic bioreductive agent-sodium borocaptate-10B conjugates as 10B-carriers in boron neutron capture therapy.

• DOI: 10.1007/bf02493275
• 发表时间: 2006-02-01
• 期刊: Radiation medicine
• 作者: Masunaga, Shin-Ichiro;Nagasawa, Hideko;Ono, Koji
• 通讯作者: Ono, Koji