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Analysis of molecular mechanisms of leukemia

Analysis of molecular mechanisms of leukemia
白血病分子机制分析
批准号:
17016042
负责人:
KANAKURA Yuzuru
金额:
$45.76万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009

项目摘要

项目成果

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中文摘要
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英文摘要
We have tried to identify signaling or anti-apoptotic molecules, which have potential for novel therapeutic targets for leukemic treatment. We analyzed the function and molecular mechanisms in hematopoietic cell growth and leukemogenesis of Anamorsin, activated c-kit and Flt3, FIP1L1-PDGFR, and RUNX1 mutations. As a result, we found that these molecules might be candidates for novel molecular targets. In addition, we also identified several molecules whose mRNA expression is observed in leukemic stem cells, but not in normal hematopoietic stem cells.
期刊论文(121)
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会议论文
DOI: 10.1074/jbc.m406788200
发表时间: 2005-02-11
期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子: 4.8
作者: [Ishiko, E, Matsumura, I, Kanakura, Y]
通讯作者: Kanakura, Y
DOI: 10.1161/01.atv.0000194076.84568.81
发表时间: 2006-01-01
期刊: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
影响因子: 8.7
作者: [Kato, H, Kashiwagi, H, Kanakura, Y]
通讯作者: Kanakura, Y
肥満細胞症
肥大细胞增多症
DOI: --
发表时间: 2009
期刊: 血液フロンティア 19巻
影响因子: --
作者: [松村到, 金倉譲]
通讯作者: 金倉譲
RUNX1はGadd45aの転写調節を介してヌクレオチド除去修復を制御する
RUNX1 通过 Gadd45a 的转录调控控制核苷酸切除修复
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [佐藤友亮, 等]
通讯作者:
101
    Functional analysis of SATB1, a global transcription regulator, in hematopoietic stem cells
    • 批准号:
      16H05339
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.07万
    • 财政年份:
      2016
    • 负责人:
      KANAKURA Yuzuru
    • 依托单位:
    Analysis of the functions of anti-apoptotic molecule, Anamorsin -the roles in hematopoiesis and cellular iron metabolism-
    • 批准号:
      25293220
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.81万
    • 财政年份:
      2013
    • 负责人:
      KANAKURA Yuzuru
    • 依托单位:
    Screening of low molecular compounds, which inhibit cell proliferation and survival
    • 批准号:
      23659488
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2011
    • 负责人:
      KANAKURA Yuzuru
    • 依托单位:
    Analysis of functions of anamorsin, an anti-apoptotic molecule, in hematopoiesis
    • 批准号:
      22390194
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.9万
    • 财政年份:
      2010
    • 负责人:
      KANAKURA Yuzuru
    • 依托单位:
    海外基金