Analysis of molecular mechanisms of leukemia

我们已经尝试确定信号或抗凋亡分子，它们有可能成为白血病治疗的新靶点。我们分析了Anamorsin、活化的c-kit和Flt3、FIP1L1-PDGFR和RUNX1突变在造血细胞生长和白血病发生中的功能和分子机制。因此，我们发现这些分子可能是新的分子靶标的候选者。此外，我们还发现了几个在白血病干细胞中观察到mRNA表达的分子，而在正常造血干细胞中则没有。

We have tried to identify signaling or anti-apoptotic molecules, which have potential for novel therapeutic targets for leukemic treatment. We analyzed the function and molecular mechanisms in hematopoietic cell growth and leukemogenesis of Anamorsin, activated c-kit and Flt3, FIP1L1-PDGFR, and RUNX1 mutations. As a result, we found that these molecules might be candidates for novel molecular targets. In addition, we also identified several molecules whose mRNA expression is observed in leukemic stem cells, but not in normal hematopoietic stem cells.