Analysis of functions of anamorsin, an anti-apoptotic molecule, in hematopoiesis
Analysis of functions of anamorsin, an anti-apoptotic molecule, in hematopoiesis
批准号:
22390194
负责人:
KANAKURA Yuzuru
金额:
$11.9万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
We clarified anamorsin (AM) played important roles on definitive hematopoiesis in both of hematopoietic stem cells and fetal liver stromal cells by using AM deficient fetal liver. Furthermore, we found AM deficiency impaired the iron homeostasis through iron/sulfur protein biogenesis and resulted in the increase of labile iron pool, the accumulation of ROS and the induction of apoptosis.
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DOI:
10.1007/s12185-010-0621-x
发表时间:
2010-06
期刊:
International Journal of Hematology
影响因子:
2.1
作者:
[T. Nagai;J. Takeuchi;N. Dobashi;Y. Kanakura;S. Taniguchi;K. Ezaki;C. Nakaseko;A. Hiraoka;M. Okada;Y. Miyazaki;T. Motoji;M. Higashihara;N. Tsukamoto;H. Kiyoi;S. Nakao;K. Shinagawa;R. Ohno;T. Naoe;K. Ohnishi;N. Usui]
通讯作者:
T. Nagai;J. Takeuchi;N. Dobashi;Y. Kanakura;S. Taniguchi;K. Ezaki;C. Nakaseko;A. Hiraoka;M. Okada;Y. Miyazaki;T. Motoji;M. Higashihara;N. Tsukamoto;H. Kiyoi;S. Nakao;K. Shinagawa;R. Ohno;T. Naoe;K. Ohnishi;N. Usui
Excessive reactive iron affects both immature hematopoietic cells and stromal cells, thereby impairing total hematopoiesis.
过量的活性铁会影响未成熟的造血细胞和基质细胞,从而损害总造血功能。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Tanaka H, et al.]
通讯作者:
et al.
Essential role of an anti-apoptotic molecule Anamorsin for both intrinsic and extrinsic regulation of murine fetal liver hematopoiesis.
抗凋亡分子阿纳莫辛对小鼠胎肝造血的内在和外在调节的重要作用。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Tanimura A, Tanaka H, et al.]
通讯作者:
et al.
がんの統合医療
综合癌症医学
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[水木満佐央, 他]
通讯作者:
他
血液疾患 最新の治療 2011-2013
2011-2013年血液病最新治疗方法
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[西村純一, 金倉譲, 他]
通讯作者:
他
共 79 条
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