Screening of low molecular compounds, which inhibit cell proliferation and survival

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We tried to establish a new anti-proliferative drug through a following process: (1) screening of compounds to inhibit Baf3 cell growth (2) identification of target molecules for the selected compounds (3) analysis of physical effects of each possible compound. We screened approximately 10,000 low molecular compounds, which were provided from Tokyo University, and successfully isolated 61 compounds. Some inhibited Baf3 cell growth, or induced apoptosis, and the others induced morphological changes. Among them, we selected 4 compounds, T-167317, T-170633, T-005170, T-051702, which is water-soluble and has a specific structure. To identify their molecular targets, we just fixed the compounds onto FG beads.