Analysis of human tumor antigens and immune responses in patients

人类肿瘤抗原和患者免疫反应分析

• 批准号: 17016048
• 负责人: NAKAYAMA Eiichi
• 金额: $ 47.68万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17016048/
• 关键词: がん免疫; がん・精巣(CT)抗原; 宿主免疫応答; 免疫回避; がんワクチン; がん抗原; NY-ESO-1; T細胞エピトープ; 癌免疫; 癌抗原; SEREX; 癌・精巣(CT)抗原; 癌ワクチン; 免疫モニタリング; がん免疫療法; がん・精巣抗原; 蛋白ワクチン; がん

For cancer vaccine, identification of cancer antigens which are highly specific to cancer and strongly immunogenic in cancer patients is necessary. We found that CCDC62, HERV-K and XAGE-1b are cancer antigens which can be used as vaccine. We also conducted a clinical trial of cancer vaccine using a complex of cholesterol hydrophobized pullulan (CHP) and NY-ESO-1 protein. Immune response was elicited after vaccination in patients and some patients showed favorable clinical course.

对于癌症疫苗，必须鉴定对癌症具有高度特异性和对癌症患者具有强烈免疫原性的癌症抗原。我们发现CCDC62、HERV-K和XAGE-1b是可以作为疫苗使用的肿瘤抗原。我们还进行了一项使用胆固醇疏水普鲁兰（CHP）和NY-ESO-1蛋白复合物的癌症疫苗的临床试验。患者接种疫苗后可引起免疫应答，部分患者临床病程良好。

项目成果

Induction of immune response against NY-ESO-1 by CHP-NY-ESO-1 vaccination and immune regulation in a melanoma patient.

通过 CHP-NY-ESO-1 疫苗接种诱导针对 NY-ESO-1 的免疫反应以及黑色素瘤患者的免疫调节。

• 发表时间: 2008
• 期刊: Cancer Immunol. Immunother. 57
• 作者: Tsuji;K.;et al.
• 通讯作者: et al.

Prolonged survival in patients with lung adenocarcinoma expressing XAGE-1b and HLA class I antigens.

表达 XAGE-1b 和 HLA I 类抗原的肺腺癌患者的生存期延长。

• 发表时间: 2008
• 期刊: Cancer Immunity 8
• 作者: Kikuchi;E.;et al.
• 通讯作者: et al.

Antibody responses against NY-ESO-1 and HER2 antigens in patients vaccinated with combinations of cholesteryl pullulan (CHP)-NY-ESO-1 and CHP-HER2 with OK-432

• DOI: 10.1016/j.vaccine.2009.09.018
• 发表时间: 2009-11-16
• 期刊: VACCINE
• 影响因子: 5.5
• 作者: Aoki, Masatoshi;Ueda, Shugo;Kageyama, Shinichi
• 通讯作者: Kageyama, Shinichi

In vitro stimulation of CD8 and CD4 T cells by dendritic cells loaded with a complex of cholesterol-bearing hydrophobized pullulan and NY-ESO-1 protein:: Identification of a new HLA-DR15-binding CD4 T-cell epitope

• DOI: 10.1158/1078-0432.ccr-05-1900
• 发表时间: 2006-03-15
• 期刊: CLINICAL CANCER RESEARCH
• 影响因子: 11.5
• 作者: Hasegawa, K;Noguchi, Y;Nakayama, E
• 通讯作者: Nakayama, E

Identification of translation products of XAGE-1 isoforms : predominant expression of XAGE-1b in testis and tumors.

XAGE-1 同种型翻译产物的鉴定：XAGE-1b 在睾丸和肿瘤中的主要表达。

• 发表时间: 2007
• 期刊: Cancer Immunity 7
• 作者: Sato;S.;et al.
• 通讯作者: et al.