Analysis of human tumor antigens and immune responses in patients
Analysis of human tumor antigens and immune responses in patients
批准号:
17016048
负责人:
NAKAYAMA Eiichi
金额:
$47.68万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009
中文摘要
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英文摘要
For cancer vaccine, identification of cancer antigens which are highly specific to cancer and strongly immunogenic in cancer patients is necessary. We found that CCDC62, HERV-K and XAGE-1b are cancer antigens which can be used as vaccine. We also conducted a clinical trial of cancer vaccine using a complex of cholesterol hydrophobized pullulan (CHP) and NY-ESO-1 protein. Immune response was elicited after vaccination in patients and some patients showed favorable clinical course.
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Prolonged survival in patients with lung adenocarcinoma expressing XAGE-1b and HLA class I antigens.
表达 XAGE-1b 和 HLA I 类抗原的肺腺癌患者的生存期延长。
DOI:
--
发表时间:
2008
期刊:
Cancer Immunity 8
影响因子:
--
作者:
[Kikuchi, E., et al.]
通讯作者:
et al.
Induction of immune response against NY-ESO-1 by CHP-NY-ESO-1 vaccination and immune regulation in a melanoma patient.
通过 CHP-NY-ESO-1 疫苗接种诱导针对 NY-ESO-1 的免疫反应以及黑色素瘤患者的免疫调节。
DOI:
--
发表时间:
2008
期刊:
Cancer Immunol. Immunother. 57
影响因子:
--
作者:
[Tsuji, K., et al.]
通讯作者:
et al.
DOI:
10.1016/j.vaccine.2009.09.018
发表时间:
2009-11-16
期刊:
VACCINE
影响因子:
5.5
作者:
[Aoki, Masatoshi, Ueda, Shugo, Kageyama, Shinichi]
通讯作者:
Kageyama, Shinichi
DOI:
10.1158/1078-0432.ccr-05-1900
发表时间:
2006-03-15
期刊:
CLINICAL CANCER RESEARCH
影响因子:
11.5
作者:
[Hasegawa, K, Noguchi, Y, Nakayama, E]
通讯作者:
Nakayama, E
プロトカドヘリン11X/Y (PCDGl1X/Y)バリアントのがん細胞における発現様式
原钙粘蛋白 11X/Y (PCDGl1X/Y) 变体在癌细胞中的表达模式
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[花房直志, 他]
通讯作者:
他
共 84 条
Use of long overlapping peptides for cancer vaccine and Treg control for potentiating immune response
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批准号:22300332
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.32万
-
财政年份:2010
-
负责人:NAKAYAMA Eiichi
-
依托单位:
Tumor immune escape and the role of CD4 regulatory T cells
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批准号:13670319
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$0.7万
-
财政年份:2001
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负责人:NAKAYAMA Eiichi
-
依托单位:
Tumor immune escape by immunoregulatory CD4 T cells
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批准号:10670304
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.79万
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财政年份:1998
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负责人:NAKAYAMA Eiichi
-
依托单位:
Induction of immune response against MHC class I-binding peptides
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批准号:07670372
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:1995
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负责人:NAKAYAMA Eiichi
-
依托单位:
Cellular mechanisms of graft rejection mediated by CD4-CD8-TCR alphabeta T cells.
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批准号:04454210
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$0.77万
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财政年份:1992
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负责人:NAKAYAMA Eiichi
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依托单位:
Proliferation of double negative (DN) gammadelta T cells in reseponse to allogeneic MHC antigen.
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批准号:02670206
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.47万
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财政年份:1990
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负责人:NAKAYAMA Eiichi
-
依托单位: