课题基金 / 基金详情

Analysis of human tumor antigens and immune responses in patients

Analysis of human tumor antigens and immune responses in patients
人类肿瘤抗原和患者免疫反应分析
批准号:
17016048
负责人:
NAKAYAMA Eiichi
金额:
$47.68万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009

项目摘要

项目成果

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中文摘要
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英文摘要
For cancer vaccine, identification of cancer antigens which are highly specific to cancer and strongly immunogenic in cancer patients is necessary. We found that CCDC62, HERV-K and XAGE-1b are cancer antigens which can be used as vaccine. We also conducted a clinical trial of cancer vaccine using a complex of cholesterol hydrophobized pullulan (CHP) and NY-ESO-1 protein. Immune response was elicited after vaccination in patients and some patients showed favorable clinical course.
期刊论文(111)
专著(0)
科研奖励(0)
会议论文
Prolonged survival in patients with lung adenocarcinoma expressing XAGE-1b and HLA class I antigens.
表达 XAGE-1b 和 HLA I 类抗原的肺腺癌患者的生存期延长。
DOI: --
发表时间: 2008
期刊: Cancer Immunity 8
影响因子: --
作者: [Kikuchi, E., et al.]
通讯作者: et al.
Induction of immune response against NY-ESO-1 by CHP-NY-ESO-1 vaccination and immune regulation in a melanoma patient.
通过 CHP-NY-ESO-1 疫苗接种诱导针对 NY-ESO-1 的免疫反应以及黑色素瘤患者的免疫调节。
DOI: --
发表时间: 2008
期刊: Cancer Immunol. Immunother. 57
影响因子: --
作者: [Tsuji, K., et al.]
通讯作者: et al.
DOI: 10.1016/j.vaccine.2009.09.018
发表时间: 2009-11-16
期刊: VACCINE
影响因子: 5.5
作者: [Aoki, Masatoshi, Ueda, Shugo, Kageyama, Shinichi]
通讯作者: Kageyama, Shinichi
DOI: 10.1158/1078-0432.ccr-05-1900
发表时间: 2006-03-15
期刊: CLINICAL CANCER RESEARCH
影响因子: 11.5
作者: [Hasegawa, K, Noguchi, Y, Nakayama, E]
通讯作者: Nakayama, E
84
    Use of long overlapping peptides for cancer vaccine and Treg control for potentiating immune response
    • 批准号:
      22300332
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.32万
    • 财政年份:
      2010
    • 负责人:
      NAKAYAMA Eiichi
    • 依托单位:
    Tumor immune escape and the role of CD4 regulatory T cells
    • 批准号:
      13670319
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $0.7万
    • 财政年份:
      2001
    • 负责人:
      NAKAYAMA Eiichi
    • 依托单位:
    Tumor immune escape by immunoregulatory CD4 T cells
    • 批准号:
      10670304
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.79万
    • 财政年份:
      1998
    • 负责人:
      NAKAYAMA Eiichi
    • 依托单位:
    Induction of immune response against MHC class I-binding peptides
    • 批准号:
      07670372
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.41万
    • 财政年份:
      1995
    • 负责人:
      NAKAYAMA Eiichi
    • 依托单位: