Molecular targeting agents that suppress invasion and metastasis of cancer cells

点击翻译按钮获取中文摘要

Thymidine phosphorylase is an enzyme that has an angiogenic activity. 2-Deoxy-D-ribose, one of the degradation products of thymidine produced by TP also has an angiogenic activity. As well as the inhibitor of TP, 2-deoxy-L-ribose, an stereoisomer of 2-deoxy-D-ribose, suppressed the growth, invasion and metastasis of the TP-expressing tumors. ROS was produced by TP and 2-deoxy-D-ribose, and the ROS activated NFκB. The activated NFκB enhanced the expression of IL-8 and MMPs that are involved in angiogenesis.