Molecular targeting agents that suppress invasion and metastasis of cancer cells

胸苷磷酸化酶是一种具有血管生成活性的酶。TP产生的胸苷降解产物2-脱氧- d -核糖也具有血管生成活性。2-脱氧-d -核糖的立体异构体2-脱氧- l -核糖作为TP的抑制剂，抑制TP表达肿瘤的生长、侵袭和转移。活性氧由TP和2-脱氧-d核糖产生，激活NFκB。活化的NFκB增强了参与血管生成的IL-8和MMPs的表达。

Thymidine phosphorylase is an enzyme that has an angiogenic activity. 2-Deoxy-D-ribose, one of the degradation products of thymidine produced by TP also has an angiogenic activity. As well as the inhibitor of TP, 2-deoxy-L-ribose, an stereoisomer of 2-deoxy-D-ribose, suppressed the growth, invasion and metastasis of the TP-expressing tumors. ROS was produced by TP and 2-deoxy-D-ribose, and the ROS activated NFκB. The activated NFκB enhanced the expression of IL-8 and MMPs that are involved in angiogenesis.