Comparative analysis of large scale genome data and knowledge discovery

点击翻译按钮获取中文摘要

We have accumulated a large amount of knowledge concerning with molecular biology by comparing biological sequences, such as DNA, RNA and amino acid sequences. On the other hand, rapid progress of sequencing technology have brought accumulation of a large amount of sequence data. Then, its quantity is now exceeding the upper limit of application of existing sequence comparison methods. Here, we have developed methods which are capable of comparing such a large amount of sequence data with high accuracy, and have tackled the challenge to biological knowledge discovery by applying the methods. As a result, we have revealed molecular mechanism of transcriptional regulation of microRNA function.