The systematic analysis on the diseases through the integration of the clinical data with the genomic information

通过临床数据与基因组信息的整合对疾病进行系统分析

• 批准号: 17019008
• 负责人: NAGAI Ryozo
• 金额: $ 103.42万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17019008/
• 关键词: データベース; ゲノム; 生活習慣病; 臨床情報; ゲノム解析; 動脈硬化; 一塩基多型; 転写制御; 虚血性心疾患; 生命システム

The onset and/or progression of the diseases could mean the expression of the "failure of the life system". The purpose of this study is to understand the life system and the mechanism of the diseases through the integration of the clinical data with the genomic information. In addition, applying its outcomes to the basic research, we could get the theoretical rationale for the best individualized medicine. In this study, we realized the construction and practical use of the systematic database system unifying the comprehensive clinical data and genomic information in the University of Tokyo Hospital. Using this database system, we examined many SNPs which were reported to be associated with cardiovascular diseases and/or diabetes, and identified novel significant SNPs. For example, the SNP in the promoter region of transcription factor KLF5 is here demonstrated to be related to the progression of cardiovascular analysis. The pathophysiological meaning of this KLF5 SNP was also clarified in this study. Like this, in this study, the integration of the clinical data with the genomic information was performed to find out the novel useful clinical markers as well as the pathophysiological mechanisms, both of which are applicable to the individualized medicine.

疾病的发作和/或进展可能意味着“生命系统衰竭”的表达。本研究的目的是通过整合临床数据和基因组信息来了解生命系统和疾病的机制。此外，将其成果应用于基础研究，可以为最佳个体化用药提供理论依据。在本研究中，我们实现了东京大学医院综合临床数据和基因组信息的系统数据库系统的构建和实际使用。使用这个数据库系统，我们检查了许多SNPs，据报道与心血管疾病和/或糖尿病，并确定了新的显着的SNPs。例如，转录因子KLF 5的启动子区域中的SNP在此被证明与心血管分析的进展相关。本研究还阐明了该KLF 5 SNP的病理生理学意义。本研究将临床数据与基因组信息相结合，寻找新的临床标记物和病理生理机制，为个体化用药提供依据。

项目成果

Adiponectin stimulates AMP-Activated protein kinase in the hypothalamus and increases food intake

• DOI: 10.1016/j.cmet.2007.06.003
• 发表时间: 2007-07-01
• 期刊: CELL METABOLISM
• 影响因子: 29
• 作者: Kubota, Naoto;Yano, Wataru;Kadowaki, Takashi
• 通讯作者: Kadowaki, Takashi

Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association

• DOI: 10.1038/jhg.2009.17
• 发表时间: 2009-04-01
• 期刊: JOURNAL OF HUMAN GENETICS
• 影响因子: 3.5
• 作者: Miyake, Kazuaki;Yang, Woosung;Kasuga, Masato
• 通讯作者: Kasuga, Masato

Acyclic retinoid inhibits functional interaction of transcription factors Kruppel-like factor 5 and retinoic acid receptor-alpha

• DOI: 10.1016/j.febslet.2008.04.040
• 发表时间: 2008-05-28
• 期刊: FEBS LETTERS
• 影响因子: 3.5
• 作者: Kada, Nanae;Suzuki, Toru;Nagai, Ryozo
• 通讯作者: Nagai, Ryozo

Cardiovascular remodeling and energy metabolism through Kruppel-like transcription factor 5.

通过 Kruppel 样转录因子 5 进行心血管重塑和能量代谢。

• 发表时间: 2009
• 作者: Hara K;Horikoshi M;Yamauchi T;Yago H;Miyazaki O;Ebinuma H;Imai Y;Nagai R;Kadowaki T.;Hara K;Nishimura G;Hara K;Kamei N;Takeda N;Kawanami D;Fujiu K;Nagai R;Matsumura T;Ishizaka N;Nagai R.
• 通讯作者: Nagai R.

Critical role of bone marrow angiotensin II type 1 receptor in the pathogenesis of atherosclerosis in apolipoprotein E-deficient mice

• DOI: 10.1161/atvbaha.107.152363
• 发表时间: 2008-01-01
• 期刊: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
• 影响因子: 8.7
• 作者: Fukuda, Daiju;Sata, Masataka;Nagai, Ryozo
• 通讯作者: Nagai, Ryozo