课题基金 / 基金详情

Pathogenesis and molecular mechanisms of arteral restenosis

Pathogenesis and molecular mechanisms of arteral restenosis
动脉再狭窄的发病机制和分子机制
批准号:
06454287
负责人:
NAGAI Ryozo
金额:
$4.99万
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (B)
财政年份:
1994
资助国家:
日本
项目状态:
已结题
起止时间:
1994 至 1995

项目摘要

项目成果

NAGAI Ryozo的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
We previously demonstrated that rabbit and rat smooth muscles contain at least three types of MHCs ; SM1(204kDa), SM2(200kDa)and SMemb(200kDa). SM1 and SM2 are two smooth muscle specific MHC isoforms arising from a singlegene, and SMemb is a third type of MHC isoform abundantly expressed in embryonic aortas. The expression of three MHC isoforms is developmentallyregulated.The presence of developmentallyregulated MHC isoforms in vascular smooth muscles provides importantmoleculartools to investigate the molecularmechanism underlying vascular diseases. We first demonstrated that the developmentalregulation of myosin heavy chain expression occurs in proliferating smooth muscle cells after percutaneous angioplasty(PTCA) ; SMemb was reexpressed and SM2 was downregulated. We therefore characterized the promoter region of the SM1/2 and SMemb genes. In this study, we identified an important cis element for the SMemb gene and a transcription factor, BTEB-2, which coordinately regulate the SMemb gene.We furthermore characterized SM1/2 gene which is most specifically expressed in smooth muscles. SM1/2 gene harbors two CCTCCC elements-80 bp upstream of the transcription initiation site. These elements play a basic role for SM1/2 gene transcription but does not necessarily regulate smooth muscle-specific expression.
期刊论文(52)
专著(0)
科研奖励(0)
会议论文
Kuroo M.,et al: "Salt-sensitinve hypertension in transgenic mice overexpressing Sodium-proton exchanger." Circulation Resarch. 76. 148-153 (1995)
Kuroo M.等人:“过度表达钠-质子交换体的转基因小鼠中的盐敏感性高血压。”
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Suzuki T,Katoh H,Suzuki S,Ohtaki E,Watanabe M,Yazaki Y,Nagai R.: "A novel biochemical diagnostic method for aortic dissection-the results of a prospective study using an immunoassay of smooth muscle myosin heavy chain." Circulation. (in press.).
Suzuki T,Katoh H,Suzuki S,Ohtaki E,Watanabe M,Yazaki Y,Nagai R.:“主动脉夹层的新型生化诊断方法 - 使用平滑肌肌球蛋白重链免疫测定的前瞻性研究结果。”
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Okamoto E. et: "Diversity of the synthetic-state smooth muscle cells proliferating in mechanically and hemodynamically injured arteries" Lab. Invest. 74. 120-128 (1996)
Okamoto E. 等人:“在机械和血流动力学损伤的动脉中增殖的合成状态平滑肌细胞的多样性”实验室。
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Kurihara Y,Kurihara H,Oda H,Maemura K,Nagai R,Ishikawa T,Yazaki Y.: "Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1." J Clin Invest. 96. 293-300 (1995)
Kurihara Y、Kurihara H、Oda H、Maemura K、Nagai R、Ishikawa T、Yazaki Y.:“内皮素-1 缺陷小鼠的主动脉弓畸形和室间隔缺损。”
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
26
    KLF network in chronic diseases and cancer
    • 批准号:
      22229006
    • 项目类别:
      Grant-in-Aid for Scientific Research (S)
    • 资助金额:
      $139.28万
    • 财政年份:
      2010
    • 负责人:
      NAGAI Ryozo
    • 依托单位:
    Molecular mechanisms that control stress response and tissue remodeling by cardiometabolic and immune systems
    • 批准号:
      19209029
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $30.45万
    • 财政年份:
      2007
    • 负责人:
      NAGAI Ryozo
    • 依托单位:
    The systematic analysis on the diseases through the integration of the clinical data with the genomic information
    • 批准号:
      17019008
    • 项目类别:
      Grant-in-Aid for Scientific Research on Priority Areas
    • 资助金额:
      $103.42万
    • 财政年份:
      2005
    • 负责人:
      NAGAI Ryozo
    • 依托单位:
    Molecular mechanism of organ remodeling : Gene transcription and cell-cell interaction in mesenchymal
    • 批准号:
      14104012
    • 项目类别:
      Grant-in-Aid for Scientific Research (S)
    • 资助金额:
      $68.89万
    • 财政年份:
      2002
    • 负责人:
      NAGAI Ryozo
    • 依托单位:
    海外基金