Higher sensory processing mechanisms investigated by transcranial imaging of mouse cortical activities

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Endogenous green fluorescence signals derived from mitochondria reflect activity-dependent changes in brain metabolism, and may be exploited in functional brain imaging. Endogenous flavoprotein fluorescence imaging in mice is especially important because the transparent skull of mice allows transcranial fluorescence imaging of cortical activities. Using this technique, we investigated cortical activities and experiencedependent plasticity in the somatosensory, visual and auditory cortices of mice.