Study on molecular mechanisms for regulating proliferation and differentiation of embryonic neural stem cells
Study on molecular mechanisms for regulating proliferation and differentiation of embryonic neural stem cells
批准号:
17024001
负责人:
OSUMI Noriko
金额:
$49.54万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009
中文摘要
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英文摘要
We investigated molecular mechanisms of proliferation and differentiation of neural stem cells especially focusing on Pax6 transcription factor, a key regulator of brain development, and its downstream molecules. We also revealed that subcellular localization of Cyclin D2, a cell cycle regulator, is crucial to keep the neural stem cells proliferative.
期刊论文(110)
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DOI:
10.1111/j.1440-169x.2007.00965.x
发表时间:
2007-10
期刊:
Development
影响因子:
4.6
作者:
[T. Nomura;Hasumi Haba;N. Osumi]
通讯作者:
T. Nomura;Hasumi Haba;N. Osumi
Role of Fabp7, a downstream gene of Pax6, in the meintenance of neuroepithelial cells during early embryonic development of the rat cortex.
Pax6 下游基因 Fabp7 在大鼠皮质早期胚胎发育过程中神经上皮细胞维持中的作用。
DOI:
--
发表时间:
2005
期刊:
J Neurosci. 25(42)
影响因子:
--
作者:
[Arai, Y., Funatsu, N., Numayama-Tsuruta, K., Nomura, T., Nakamura, S., Osumi, N.]
通讯作者:
N.
Role of Fabp7, a downstream gene of Pax6, in maintenance of neuroepithelialcells during early embryonic development of the rat cortex.
Fabp7(Pax6 的下游基因)在大鼠皮质早期胚胎发育过程中神经上皮细胞维持中的作用。
DOI:
--
发表时间:
2005
期刊:
The Journal of Neuroscience 25(42)
影响因子:
--
作者:
[Arai, Y., Funatsu, N., Numayama-Tsuruta, K., Nomura, T., Nakamura, S., Osumi, N.]
通讯作者:
N.
Proliferation of glial cells : its implication for the healthy brain.
神经胶质细胞的增殖:对健康大脑的影响。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Osumi, N.]
通讯作者:
N.
Downregulation of ninein, delta-catenin and FEZ1 at the apical side of neuroepithelial cells of the Pax6 mutant
Pax6 突变体神经上皮细胞顶端的 ninein、δ-catenin 和 FEZ1 下调
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Shinohara, H., Hayashi, K., Miyata, T., Takahashi, M. and Osumi. N.]
通讯作者:
M. and Osumi. N.
共 92 条
Epigenetic changes of male germ line cells affecting behavior of offspring in mice
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批准号:15K12764
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2015
-
负责人:OSUMI Noriko
-
依托单位:
The role of RNA-binding protein for long-distance transportation of mRNA within embryonic neural progenitor cells
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批准号:26291046
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.65万
-
财政年份:2014
-
负责人:OSUMI Noriko
-
依托单位:
Analysis on the neural basis for vocal communication in the mouse
-
批准号:25640002
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.58万
-
财政年份:2013
-
负责人:OSUMI Noriko
-
依托单位:
Participation of the oligodendrocyte/oligodendrocyte precursor cell in the morbidity of schizophrenia
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批准号:23650186
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2011
-
负责人:OSUMI Noriko
-
依托单位:
Roles of fatty acids and fatty acid binding proteins for regulating proliferation and differentiation of neural stem cells
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批准号:21300115
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$12.15万
-
财政年份:2009
-
负责人:OSUMI Noriko
-
依托单位:
Establishment of novel techniques for manipulating mammalian fetuses at the molecular level
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批准号:11558090
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$8.64万
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财政年份:1999
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负责人:OSUMI Noriko
-
依托单位:
The role of Pax6 gene in vertebrate neural development
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批准号:11470002
-
项目类别:Grant-in-Aid for Scientific Research (B).
-
资助金额:$10.82万
-
财政年份:1999
-
负责人:OSUMI Noriko
-
依托单位:
Abnormal Craniofacial Morphogenesis of the Small Eye Rat
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批准号:08457475
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$4.86万
-
财政年份:1996
-
负责人:OSUMI Noriko
-
依托单位:
海外基金