Elucidating the role of extracellular matrix remodeling on the fate and behavior of neuron

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RECK, first identified as a transformation suppressor gene, is expressed at relatively high levels in neural precursor cells (NPCs) in mouse embryos; in Reck-deficient mice, NPCs show reduced proliferation and precocious differentiation. Our study to understand the mechanism of this phenomenon revealed that Reck inhibits ADAM10- mediated Notch-ligand shedding. We also found that in the diaphragm of late-stage embryos, Reck rapidly accumulates in the neuromuscular junctions, mainly in the secondary folds of the post-synaptic muscle membrane.