Genetic analysis of central nervous system by using conditional mutant mice

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We established the mGluR1 cKO mice in which mGluR1 expression can be turned off with doxycycline. Using mGluR1 cKO mice, we showed that mGluR1 is essential for motor coordination in adulthood and that conditioned eyeblink memory was not formed without mGluR1 but once formed memory was maintained and expressed without mGluR1.We also showed that a Rho family GTPase Rac1 specifically controls the midline crossing of the commissural axons during cortical development, rather than neuronal migration and axonal formation.