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Comprehensive analysis of in vivo substrates of protein kinase C

Comprehensive analysis of in vivo substrates of protein kinase C
蛋白激酶C体内底物综合分析
批准号:
23650214
负责人:
AIBA Atsu
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
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英文摘要
Protein kinase C (PKC) γ is involved in cerebellar functions such as motor coordination and elimination of climbing fiber-Purkinje cell synapses. Molecular mechanisms of PKCγ-regulating cerebellar processes are elusive, due to the heretofore undescribed in vivo substrates of PKCγ. In this study, a series of candidate molecules for PKCγ substrates in mouse cerebellum was identifiedby quantitative phospho-proteomic analysis.
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Suppression of a neocortical potassium channel activity by intracellular amyloid-ss and its rescue with Homer1a
细胞内淀粉样蛋白-ss对新皮质钾通道活性的抑制及其用Homer1a的拯救
DOI: --
发表时间: 2011
期刊: Journal of Neuroscience
影响因子: 5.3
作者: [Yamamoto K, Ueta Y, Wang L, Yamamoto R, Inoue N, Inokuchi K, Aiba A, Yonekura H, Kato N]
通讯作者: Kato N
中枢神経系において恒常的活性化型mTORを発現するマウスの作製と解析
中枢神经系统中表达组成型激活 mTOR 的小鼠的生成和分析
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Yamamoto K, Ueta Y, Wang L, Yamamoto R, Inoue N, Inokuchi K, Aiba A, Yonekura H, Kato N., 饗場篤]
通讯作者: 饗場篤
DOI: 10.1007/s00125-013-2849-5
发表时间: 2013-05
期刊: DIABETOLOGIA
影响因子: 8.2
作者: [Asahara, S., Shibutani, Y., Teruyama, K., Inoue, H. Y., Kawada, Y., Etoh, H., Matsuda, T., Kimura-Koyanagi, M., Hashimoto, N., Sakahara, M., Fujimoto, W., Takahashi, H., Ueda, S., Hosooka, T., Satoh, T., Inoue, H., Matsumoto, M., Aiba, A., Kasuga, M., Kido, Y.]
通讯作者: Kido, Y.
Genetic dissection of mGluR1 function in cerebellar Purkinje cells
小脑浦肯野细胞 mGluR1 功能的基因剖析
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [齊郷平, 今井裕子, 岡村康司, 井上隆司, 森誠之, Takakusaki K, Aiba A]
通讯作者: Aiba A
8
    Roles of mTOR in neuronal development, synaptic plasticity and learning and memory
    • 批准号:
      22300106
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.48万
    • 财政年份:
      2010
    • 负责人:
      AIBA Atsu
    • 依托单位:
    Neuronal development and synaptic plasticity in Cdc42 cenditional knockout mice
    • 批准号:
      18300106
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.53万
    • 财政年份:
      2006
    • 负责人:
      AIBA Atsu
    • 依托单位:
    Genetic analysis of central nervous system by using conditional mutant mice
    • 批准号:
      17024038
    • 项目类别:
      Grant-in-Aid for Scientific Research on Priority Areas
    • 资助金额:
      $67.71万
    • 财政年份:
      2005
    • 负责人:
      AIBA Atsu
    • 依托单位:
    Investigation of signal transduction in cerebellar Purkinje cell by in vivo expression of pertusis toxin.
    • 批准号:
      16300099
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.6万
    • 财政年份:
      2004
    • 负责人:
      AIBA Atsu
    • 依托单位:
    海外基金