Comprehensive analysis of in vivo substrates of protein kinase C
Comprehensive analysis of in vivo substrates of protein kinase C
批准号:
23650214
负责人:
AIBA Atsu
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
Protein kinase C (PKC) γ is involved in cerebellar functions such as motor coordination and elimination of climbing fiber-Purkinje cell synapses. Molecular mechanisms of PKCγ-regulating cerebellar processes are elusive, due to the heretofore undescribed in vivo substrates of PKCγ. In this study, a series of candidate molecules for PKCγ substrates in mouse cerebellum was identifiedby quantitative phospho-proteomic analysis.
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Suppression of a neocortical potassium channel activity by intracellular amyloid-ss and its rescue with Homer1a
细胞内淀粉样蛋白-ss对新皮质钾通道活性的抑制及其用Homer1a的拯救
DOI:
--
发表时间:
2011
期刊:
Journal of Neuroscience
影响因子:
5.3
作者:
[Yamamoto K, Ueta Y, Wang L, Yamamoto R, Inoue N, Inokuchi K, Aiba A, Yonekura H, Kato N]
通讯作者:
Kato N
中枢神経系において恒常的活性化型mTORを発現するマウスの作製と解析
中枢神经系统中表达组成型激活 mTOR 的小鼠的生成和分析
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Yamamoto K, Ueta Y, Wang L, Yamamoto R, Inoue N, Inokuchi K, Aiba A, Yonekura H, Kato N., 饗場篤]
通讯作者:
饗場篤
DOI:
10.1007/s00125-013-2849-5
发表时间:
2013-05
期刊:
DIABETOLOGIA
影响因子:
8.2
作者:
[Asahara, S., Shibutani, Y., Teruyama, K., Inoue, H. Y., Kawada, Y., Etoh, H., Matsuda, T., Kimura-Koyanagi, M., Hashimoto, N., Sakahara, M., Fujimoto, W., Takahashi, H., Ueda, S., Hosooka, T., Satoh, T., Inoue, H., Matsumoto, M., Aiba, A., Kasuga, M., Kido, Y.]
通讯作者:
Kido, Y.
Genetic dissection of mGluR1 function in cerebellar Purkinje cells
小脑浦肯野细胞 mGluR1 功能的基因剖析
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[齊郷平, 今井裕子, 岡村康司, 井上隆司, 森誠之, Takakusaki K, Aiba A]
通讯作者:
Aiba A
「mTORシグナルによる脳機能の調節と破綻」細胞工学
“mTOR信号对大脑功能的调节和破坏”细胞工程
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[M. Higuchi, D. Oyama, Y. Adachi, G. Uehara, 葛西秀俊,饗場篤]
通讯作者:
葛西秀俊,饗場篤
共 8 条
Roles of mTOR in neuronal development, synaptic plasticity and learning and memory
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批准号:22300106
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.48万
-
财政年份:2010
-
负责人:AIBA Atsu
-
依托单位:
Neuronal development and synaptic plasticity in Cdc42 cenditional knockout mice
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批准号:18300106
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.53万
-
财政年份:2006
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负责人:AIBA Atsu
-
依托单位:
Genetic analysis of central nervous system by using conditional mutant mice
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批准号:17024038
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$67.71万
-
财政年份:2005
-
负责人:AIBA Atsu
-
依托单位:
Investigation of signal transduction in cerebellar Purkinje cell by in vivo expression of pertusis toxin.
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批准号:16300099
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.6万
-
财政年份:2004
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负责人:AIBA Atsu
-
依托单位:
Analysis of cerebellar function by using inducible mGluRl transgenic mice.
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批准号:14380368
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.6万
-
财政年份:2002
-
负责人:AIBA Atsu
-
依托单位:
Study of novel Ras signaling pathway using ras knockout mice
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批准号:10480197
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$7.87万
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财政年份:1998
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负责人:AIBA Atsu
-
依托单位:
海外基金