Elucidation of molecular pathomechanisms of schizophrenia

为了阐明精神分裂症的分子基础，根据精神分裂症及其药理模型通常发生在特定的产后时期，我们探索并检测了来自大鼠脑区域的发育调节的精神分裂症模仿诱导基因，作为精神分裂症相关分子的新候选分子。此外，我们还分别克隆并阐明了与内源性d -丝氨酸信号调控密切相关的两个基因及其神经胶质调控机制，为进一步研究NMDA型谷氨酸受体及其协同激动剂d -丝氨酸在精神分裂症脑内可能出现的功能障碍提供线索。

To clarify the molecular basis of schizophrenia, we have explored and detected the developmentally regulated schizophrenomimetic-inducible genes from the rat brain regions as thenovel candidates for schizophrenia-associated molecules in terms of the phenomena that schizophrenia and its pharmacological models usually occur after the specific postnatal period.Moreover, we have newly cloned and clarified the two genes and the glial regulation, respectively,which are closely related to the endogenous D-serine signal controls to get further cues for theinvestigation on the possible dysfunction of the NMDA type glutamate receptor and its co-agonistD-serine in the schizophrenia brains.