Analysis of immune mechanisms of Alzheimer's disease and development of a novel treatment

阿尔茨海默病的免疫机制分析及新疗法的开发

• 批准号: 17025056
• 负责人: TABIRA Takeshi
• 金额: $ 37.31万
• 依托单位: Juntendo University (2008-2009)National Institute for Longevity Sciences,NCGG (2005-2007)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17025056/
• 关键词: アルツハイマー病; アミロイド; ワクチン; 漢方薬; ミクログリア; モノクローナル抗体; 十全大補湯; 免疫; amyloid; 老人斑; 老人班

An herbal medicine Juzentaihoto activated bone marrow-derived macrophage/microglia and enhanced clearance of senile plaque amyloid. We established a new monoclonal antibody 3.4A10, which recognized a conformational structure of Aβ42, reduced senile plaque amyloid as well as Aβ oligomers, and improved cognitive functions without enhancing cerebral micro-hemorrhages. This is expected to be used as a disease modifying antibody.

草药Juzentaihoto激活骨髓来源的巨噬细胞/小胶质细胞，并增强老年斑淀粉样蛋白的清除。我们建立了一种新的单克隆抗体3.4A10，它识别Aβ42的构象结构，减少老年斑淀粉样蛋白和Aβ寡聚体，改善认知功能，而不增加大脑微血管。这有望用作疾病修饰抗体。

项目成果

AGE-RELATED SPATIAL WORKING MEMORY IMPAIRMENT IS CAUSED BY PREFRONTAL CORTICAL DOPAMINERGIC DYSFUNCTION IN RATS

• DOI: 10.1016/j.neuroscience.2009.05.023
• 发表时间: 2009-09-15
• 期刊: NEUROSCIENCE
• 影响因子: 3.3
• 作者: Mizoguchi, K.;Shoji, H.;Tabira, T.
• 通讯作者: Tabira, T.

Anxiolytic effect of a herbal medicine, yokukansan, in aged rats: Involvement of serotonergic and dopaminergic transmissions in the prefrontal cortex

• DOI: 10.1016/j.jep.2009.09.048
• 发表时间: 2010-01-08
• 期刊: JOURNAL OF ETHNOPHARMACOLOGY
• 影响因子: 5.4
• 作者: Mizoguchi, Kazushige;Tanaka, Yayoi;Tabira, Takeshi
• 通讯作者: Tabira, Takeshi

Tissue preconditioning may explain concentric lesions in Balo's type of multiple sclerosis

• DOI: 10.1093/brain/awh457
• 发表时间: 2005-05-01
• 期刊: BRAIN
• 影响因子: 14.5
• 作者: Stadelmann, C;Ludwin, S;Lassmann, H
• 通讯作者: Lassmann, H

Development and characterization of a TAPIR-like mouse monoclonal antibody to Aβ

TAPIR 样小鼠 Aβ 单克隆抗体的开发和表征

• 发表时间: 2008
• 期刊: J Alzheim Dis 14
• 作者: Wang;J.;Hara;H.;Makifuchi;T.;Tabira;T.
• 通讯作者: T.

Oral vaccination with a recombinant adeno-associated viral vector attenuates age-related Abeta accumulation and memory deficits without lymphocytic infiltration in Tg2576 mice

口服重组腺相关病毒载体疫苗可减轻 Tg2576 小鼠与年龄相关的 Abeta 积累和记忆缺陷，且无淋巴细胞浸润

• 发表时间: 2007
• 期刊: FASEB J. 21
• 作者: Mouri;A.;Noda;Y.;Hara;H.;Mizoguchi;H.;Tabira;T.;Nabeshima;T.
• 通讯作者: T.