Studies of concentric sclerosis (Balo) in the Philippines
菲律宾的同心圆硬化症(Balo)研究
基本信息
- 批准号:05044194
- 负责人:
- 金额:$ 4.16万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for international Scientific Research
- 财政年份:1993
- 资助国家:日本
- 起止时间:1993 至 1994
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We investigated the patients with Balo's concentric sclerosis in the Philippines. A total of 34 cases was collected in 2 years. Mean age of onset was 26.5 years and male to female ratio was 1 : 1.6. Patients developed acute onset of behavioral change, muteness, quadi- or hemiplegia with double incontinence, and responded to steroids. CSF was not remarkable except for slightly elevated white blood cell count and IgG,and MRI showed multifocal or diffuse confluent lesions in the cerebral white matter. The clinical course was monophasic except for one who showed one relapse. We found 2 familial cases. HLA-DRB1*1502 was found in 74% of Balo's patients, which was significantly higher than controls (36%) . Moreover, homozygote of DRB1*1502 was found in 44% of Balo's patients, which was significantly higher than MS (0%) and controls (5.6%) . No significant immune response to myelin basic protein and proteolipid protein was found, and none of virus antibodies were significant.
我们调查了菲律宾的Balo同心圆硬化症患者。2年共收集34例。平均发病年龄为26.5岁,男女比例为1:1.6。患者出现急性发作的行为改变、缄默、四肢或偏瘫伴双失禁,并对类固醇有反应。除白色血细胞计数和IgG轻微升高外,CSF无显著变化,MRI显示大脑白色物质中有多灶性或弥漫性融合病变。除1例复发外,临床病程均为单相。我们发现了两个家族病例。HLA-DRB1 * 1502在Balo患者中的阳性率为74%,显著高于对照组(36%)。Balo病组DRB 1 * 1502纯合子的检出率为44%,显著高于MS组(0%)和对照组(5.6%)。对髓鞘碱性蛋白和蛋白脂质蛋白免疫反应不明显,病毒抗体均不明显。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
田中 武: "同心円硬化症" 日本臨床. 52. 2971-2975 (1994)
Takeshi Tanaka:“同心硬化”日本临床杂志 52. 2971-2975 (1994)。
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- 影响因子:0
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TABIRA Takeshi其他文献
TABIRA Takeshi的其他文献
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{{ truncateString('TABIRA Takeshi', 18)}}的其他基金
Analysis of immune mechanisms of Alzheimer's disease and development of a novel treatment
阿尔茨海默病的免疫机制分析及新疗法的开发
- 批准号:
17025056 - 财政年份:2005
- 资助金额:
$ 4.16万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
Identification of aging-related factors that facilitate Alzheimer's disease
识别促进阿尔茨海默病的衰老相关因素
- 批准号:
12210021 - 财政年份:2000
- 资助金额:
$ 4.16万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
ミクログリアに発現しマクロファージに発現しない遺伝子の同定
鉴定在小胶质细胞而非巨噬细胞中表达的基因
- 批准号:
10470158 - 财政年份:1998
- 资助金额:
$ 4.16万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Molecular cloning of IL-3 receptor-associated antigen
IL-3受体相关抗原的分子克隆
- 批准号:
08457198 - 财政年份:1996
- 资助金额:
$ 4.16万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Analysis of pathomechanism of autommune encephalomyelitis and development of new therapeutic strategies.
自身免疫性脑脊髓炎发病机制分析及新治疗策略开发。
- 批准号:
03454245 - 财政年份:1991
- 资助金额:
$ 4.16万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
Cloning of encephalitogenic T cells and analysis of immune mechanisms and treatment of experimental autoimmune encephalomyelitis.
实验性自身免疫性脑脊髓炎致脑炎T细胞的克隆及免疫机制分析及治疗。
- 批准号:
60480225 - 财政年份:1985
- 资助金额:
$ 4.16万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
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