Studies of concentric sclerosis (Balo) in the Philippines
Studies of concentric sclerosis (Balo) in the Philippines
批准号:
05044194
负责人:
TABIRA Takeshi
金额:
$4.16万
依托单位国家:
日本
项目类别:
Grant-in-Aid for international Scientific Research
财政年份:
1993
资助国家:
日本
项目状态:
已结题
起止时间:
1993 至 1994
中文摘要
我们调查了菲律宾的Balo同心圆硬化症患者。2年共收集34例。平均发病年龄为26.5岁,男女比例为1:1.6。患者出现急性发作的行为改变、缄默、四肢或偏瘫伴双失禁,并对类固醇有反应。除白色血细胞计数和IgG轻微升高外,CSF无显著变化,MRI显示大脑白色物质中有多灶性或弥漫性融合病变。除1例复发外,临床病程均为单相。我们发现了两个家族病例。HLA-DRB 1 *1502在Balo患者中的阳性率为74%,显著高于对照组(36%)。Balo病组DRB 1 *1502纯合子的检出率为44%,显著高于MS组(0%)和对照组(5.6%)。对髓鞘碱性蛋白和蛋白脂质蛋白免疫反应不明显,病毒抗体均不明显。
英文摘要
We investigated the patients with Balo's concentric sclerosis in the Philippines. A total of 34 cases was collected in 2 years. Mean age of onset was 26.5 years and male to female ratio was 1 : 1.6. Patients developed acute onset of behavioral change, muteness, quadi- or hemiplegia with double incontinence, and responded to steroids. CSF was not remarkable except for slightly elevated white blood cell count and IgG,and MRI showed multifocal or diffuse confluent lesions in the cerebral white matter. The clinical course was monophasic except for one who showed one relapse. We found 2 familial cases. HLA-DRB1*1502 was found in 74% of Balo's patients, which was significantly higher than controls (36%) . Moreover, homozygote of DRB1*1502 was found in 44% of Balo's patients, which was significantly higher than MS (0%) and controls (5.6%) . No significant immune response to myelin basic protein and proteolipid protein was found, and none of virus antibodies were significant.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
田中 武: "同心円硬化症" 日本臨床. 52. 2971-2975 (1994)
Takeshi Tanaka:“同心硬化”日本临床杂志 52. 2971-2975 (1994)。
DOI:
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发表时间:
期刊:
影响因子:
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作者:
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通讯作者:
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