mechanisms of chromosome regulation by Cdc7 kinase

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Cdc7 kinase plays critical roles in initiation of DNA replication. Additional important functions of Cdc7 in other chromosome transactions have been suggested. This includes meiotic recombination, DNA damage bypass (Trans-legion synthesis), and DNA replication checkpoint and so forth. We identified critical substrates of Cdc7 kinase in these processes. We also identified novel fission yeast mutations that can bypass the requirement of Hsk1 kinase for the growth. Characterization of these mutants lead to identification of some of the novel mechanisms that contribute to the plastic regulation of timing and site selection of origin firing.