Customization and cellular recognition of the extracellular matrix

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The critical amino acid residue defining the integrin binding site of laminins has been identified within the C-terminal region of the gamma chains. Integrin alpha8beta1 was found to specifically bind to nephronectin, a basement membrane protein containing the RGD cell-adhesive motif. Mice deficient in QBRICK, another basement membrane protein containing the RGD motif, were produced. The mice exhibit the phenotypes similar to those of Fraser syndrome, including fused eyelids and fingers, skin blisters, and kidney malformation.