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Molecular mechanisms of basement membrane recognition by integrins

Molecular mechanisms of basement membrane recognition by integrins
整合素识别基底膜的分子机制
批准号:
20370046
负责人:
SEKIGUCHI Kiyotoshi
金额:
$12.9万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
Affinity and specificity of interactions between the integrin family of cell adhesion receptors and their ligands of basement membranes are quantitatively explored with an emphasis on laminins, nephronectin, and other Arg-Gly-Asp motif-containing proteins. A novel protocol for collectively visualizing integrin ligands on tissue specimens has also been developed.
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DOI: 10.1016/j.cell.2011.01.014
发表时间: 2011-02-18
期刊: Cell
影响因子: 64.5
作者: [Fujiwara H, Ferreira M, Donati G, Marciano DK, Linton JM, Sato Y, Hartner A, Sekiguchi K, Reichardt LF, Watt FM]
通讯作者: Watt FM
The C-terminmal region of lamin β chains modulates the lntegrinbinding affinities of laminins.
层粘连蛋白 β 链的 C 末端区域调节层粘连蛋白的整合素结合亲和力。
DOI: --
发表时间: 2009
期刊: J. Biol. Chem. 284(in press)
影响因子: --
作者: [Taniguchi, Y., et al.]
通讯作者: et al.
The carboxyl-terminal region of laminin b chains modulates the integrin binding activity of laminins.
层粘连蛋白 b 链的羧基末端区域调节层粘连蛋白的整合素结合活性。
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Taniguchi, Y., Ido, H., Sanzen, N., Hayashi, M., Nakano, I., Nishiuchi, R., Futaki, S., Sekiguchi, K.]
通讯作者: K.
Molecular basis of basement membrane recognition by integrins
整合素识别基底膜的分子基础
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Sekiguchi, K.]
通讯作者: K.
31
    Mechanisms of basement membrane recognition by cell with special reference to cell adhesion-dependent signal transduction
    • 批准号:
      18370044
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.03万
    • 财政年份:
      2006
    • 负责人:
      SEKIGUCHI Kiyotoshi
    • 依托单位:
    Customization and cellular recognition of the extracellular matrix
    • 批准号:
      17082005
    • 项目类别:
      Grant-in-Aid for Scientific Research on Priority Areas
    • 资助金额:
      $41.6万
    • 财政年份:
      2005
    • 负责人:
      SEKIGUCHI Kiyotoshi
    • 依托单位:
    Regulatory mechanisms of ligand binding and signaling events of laminin-binding integrins
    • 批准号:
      15370055
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.47万
    • 财政年份:
      2003
    • 负责人:
      SEKIGUCHI Kiyotoshi
    • 依托单位:
    Studies on the Regulatory Mechanisms and Molecular Diversity of Integrinmediated Signal Transduction
    • 批准号:
      12480189
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $7.74万
    • 财政年份:
      2000
    • 负责人:
      SEKIGUCHI Kiyotoshi
    • 依托单位:
    海外基金