Investigations on D-lactate metabolism in neonatal calves with and without diarrhea

腹泻与非腹泻新生犊牛D-乳酸代谢的研究

• 批准号: 502371265
• 负责人: Privatdozent Dr. Florian Trefz
• 金额: --
• 依托单位: Klinik für Wiederkäuer
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/502371265?language=en
• 关键词: Investigations; lactate; metabolism; neonatal; calves

In spite of well-known preventive strategies, neonatal diarrhea in calves remains worldwide a leading source of mortality and economic losses in all bovine production systems. Clinical consequences in affected animals do not only arise from dehydration due to excessive fluid losses, but also from the occurrence of metabolic acidosis. Increased blood D-lactate concentrations as a result of bacterial fermentation processes in the gastrointestinal tract are playing a major role in the development of metabolic acidosis. They also have a major impact on the associated clinical picture which is characterized by severe depression, neurological abnormalities, and impairments of the ability to stand.The aim of the intended research project described here is to assess whether an experimentally induced strong ion (metabolic) acidosis affects D-lactate metabolism in neonatal calves. A further aim of this project is to assess how different dosages of sodium bicarbonate and rehydration with lactated Ringer's solution (containing a racemic mixture of D- and L-lactate) affect D-lactate clearance in acidotic calves with naturally acquired diarrhea. Results of this research project are expected to result in an improved understanding of D-lactate metabolism in neonatal diarrheic calves and will likely have an impact on treatment recommendations and optimization of intravenous fluid protocols for these animals.

尽管有众所周知的预防策略，但新生小牛腹泻仍然是世界范围内所有牛生产系统中死亡率和经济损失的主要来源。受影响动物的临床后果不仅来自由于过度液体损失引起的脱水，而且来自代谢性酸中毒的发生。由于胃肠道中细菌发酵过程导致的血液D-乳酸盐浓度增加在代谢性酸中毒的发展中起主要作用。他们也有一个重大的影响，其特征是严重的抑郁症，神经系统异常，并损害了站立的能力相关的临床图片。这里描述的目的是研究项目的目的是评估是否实验诱导的强离子（代谢）酸中毒影响D-乳酸代谢新生小牛。本项目的另一个目的是评估不同剂量的碳酸氢钠和乳酸林格氏溶液（含有D-和L-乳酸盐的外消旋混合物）补液如何影响自然获得性腹泻酸中毒小牛的D-乳酸盐清除率。该研究项目的结果预计将导致更好地了解新生犊牛的D-乳酸代谢，并可能对这些动物的治疗建议和静脉输液方案的优化产生影响。